261709-49-3

Upstream product

• 1950-69-2 toluene-p-sulfonyl bromide 
• 261709-34-6 2-Amino-7-isopropyl-4-methyl-benzothiazole-6-thiol 
• 2051-53-8 5-isopropyl-2-methylphenylamine 
• 261711-74-4 7-isopropyl-4-methyl-6-thiocyanato-benzothiazol-2-yl-amine 

Downstream Products

• 261706-24-5 (S)-3-(2-Amino-7-isopropyl-4-methyl-benzothiazol-6-ylsulfanyl)-4-hydroxy-6-[2-(4-hydroxyl-phenyl)-ethyl]-6-isopropyl-5,6-dihydro-pyran-2-one 
• 261706-23-4 (S)-3-(2-Amino-7-isopropyl-4-methyl-benzothiazol-6-yl-sulfanyl)-4-hydroxy-6-isopropyl-6-phenethyl-5,6-dihydro-pyran-2-one 

Relevant academic research and scientific papers

Thiocyanation of alkylanilines. A simple and efficient synthesis of thiosulfonates containing 2-aminobenzothiazole

Thiocyanation of anilines was used to introduce a thiol functionality and to construct the aminothiazole ring, all in a single step. A systematic study of thiocyanation of alkyl anilines was investigated to understand the regio-chemistry of the reaction. X-Ray crystal structures of two 2- aminobenzothiazoles were determined to assign the structures without any ambiguity. The intermediates obtained were further expanded to thiosulfonates containing 2-aminobenzothiazoles, which are extremely valuable intermediates to synthesize HIV protease inhibitors. (C) 2000 Elsevier Science Ltd.