2051-53-8

Basic information

• Product Name: 2-METHYL-5-ISOPROPYLANILINE
• Synonyms: cymidine;2-Methyl-5-(1-methylethyl)aniline;2-Methyl-5-(1-methylethyl)benzenamine;(5-isopropyl-2-methyl-phenyl)amine;2-methyl-5-propan-2-ylaniline;2-methyl-5-propan-2-yl-aniline;2-Amino-p-cymene 5-Isopropyl-2-methylaniline 5-Isopropyl-o-toluidine;5-Isopropyl-2-methylaniline [2-amino-4-isopropyltoluene]
• CAS NO: 2051-53-8
• Molecular Formula: C₁₀H₁₅N
• Molecular Weight: 149.23
• Mol File: 2051-53-8.mol
• Article Data: 3

Chemical Properties

• Melting Point: -16°C
• Boiling Point: 240.76°C (estimate)
• Flash Point: 187.1°C
• Appearance: /
• Density: 0.95
• Vapor Pressure: 0.0356mmHg at 25°C
• Refractive Index: 1.5380 to 1.5420
• Storage Temp.: 2-8°C(protect from light)
• PKA: 4.53±0.10(Predicted)
• CAS DataBase Reference: 2-METHYL-5-ISOPROPYLANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYL-5-ISOPROPYLANILINE(2051-53-8)
• EPA Substance Registry System: 2-METHYL-5-ISOPROPYLANILINE(2051-53-8)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 2051-53-8(Hazardous Substances Data)

Usage

General Description

2-Methyl-5-isopropylaniline is a chemical compound with the molecular formula C10H15N. It is a colorless to pale yellow liquid that is insoluble in water but soluble in organic solvents. 2-METHYL-5-ISOPROPYLANILINE is widely used in the production of dyes, pigments, and pharmaceuticals. It is also used as an intermediate in the synthesis of various other organic compounds. 2-Methyl-5-isopropylaniline has been found to have moderate acute toxicity and can cause irritation to the skin, eyes, and respiratory system. Therefore, proper safety precautions should be taken when handling this chemical.

InChI:InChI=1/C10H15N/c1-7(2)9-5-4-8(3)10(11)6-9/h4-7H,11H2,1-3H3

Upstream product

• 2051-55-0 (S)-p-mentha-6,8-dien-2-one-(Z)-oxime 
• 1048389-81-6 2-(3-amino-4-methyl-phenyl)-propan-2-ol 
• 943-15-7 2-nitro-p-cymene 
• 14435-92-8 carbonyl azide 
• 99-87-6 4-methylisopropylbenzene 
• 7647-01-0 hydrogenchloride 
• 63843-07-2 p-mentha-4⁽⁸⁾,6-dien-2-one oxime 
• 31198-76-2 carvoxime 
• 7664-93-9 sulfuric acid 
• 499-75-2 carvacrol 
• 40267-59-2 thujone oxime 
• 10034-85-2 hydrogen iodide 
• 64-17-5 ethanol 
• 2437-76-5 2-bromo-p-cymene 

Downstream Products

• 855699-76-2 N,N'-bis-(5-isopropyl-2-methyl-phenyl)-thiourea 
• 13540-92-6 acetic acid-(5-isopropyl-2-methyl-anilide) 
• 109245-34-3 N-(5-isopropyl-2-methyl-phenyl)-N'-phenyl-urea 
• 132594-95-7 3-chloro-propionic acid-(5-isopropyl-2-methyl-anilide) 
• 1079178-53-2 4-bromo-5-isopropyl-2-methylaniline 
• 372155-11-8 4-amino-2-isopropyl-5-methyl-benzenesulfonic acid 
• 860405-03-4 bis-(4-amino-2-isopropyl-5-methyl-phenyl)-phenyl-methane 
• 860405-06-7 N-(4-amino-2-isopropyl-5-methyl-benzhydryl)-5-isopropyl-2-methyl-aniline 
• 171075-55-1 2-Isocyanato-p-cymol 
• 13540-91-5 5-isopropyl-2,N,N-trimethyl-aniline 

Relevant articles and documents

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Direct conversion of phenols into primary anilines with hydrazine catalyzed by palladium

Primary anilines are essential building blocks to synthesize various pharmaceuticals, agrochemicals, pigments, electronic materials, and others. To date, the syntheses of primary anilines mostly rely on the reduction of nitroarenes or the transition-metal-catalyzed Ullmann, Buchwald-Hartwig and Chan-Lam cross-coupling reactions with ammonia, in which non-renewable petroleum-based chemicals are typically used as feedstocks via multiple step syntheses. A long-standing scientific challenge is to synthesize various primary anilines directly from renewable sources. Herein, we report a general method to directly convert a broad range of phenols into the corresponding primary anilines with the cheap and widely available hydrazine as both amine and hydride sources with simple Pd/C as the catalyst.

Reduction of 2-Nitro-p-cymene

Commercial 2-nitro-p-cymene has been carefully purified, and the following reduction products have been prepared: trans-2,2'-azo-p-cymene; 2,2'-hydrazo-p-cymene and its hydrochloride; 2-amino-p-cymene and its hydrochloride; and 2,2'-diisopropyl-5,5'-dimet