2051-53-8

Usage

Uses

Used in Chemical Synthesis:
2-Methyl-5-isopropylaniline is used as an intermediate in the synthesis of various organic compounds, contributing to the creation of a diverse array of chemical products.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, 2-Methyl-5-isopropylaniline is utilized as a building block for the development of new drugs, playing a crucial role in medicinal chemistry.
Used in Dye and Pigment Production:
2-METHYL-5-ISOPROPYLANILINE is employed as a key component in the production of dyes and pigments, which are essential for coloring textiles, plastics, and other materials.
Safety Considerations:
Given its moderate acute toxicity, 2-Methyl-5-isopropylaniline can cause irritation to the skin, eyes, and respiratory system. Therefore, it is imperative to exercise proper safety precautions when handling this chemical to minimize health risks.

InChI:InChI=1/C10H15N/c1-7(2)9-5-4-8(3)10(11)6-9/h4-7H,11H2,1-3H3

Upstream product

• 14435-92-8 carbonyl azide 
• 99-87-6 4-methylisopropylbenzene 
• 499-75-2 carvacrol 
• 63843-07-2 p-mentha-4⁽⁸⁾,6-dien-2-one oxime 
• 943-15-7 2-nitro-p-cymene 
• 2051-55-0 (S)-p-mentha-6,8-dien-2-one-(Z)-oxime 
• 1048389-81-6 2-(3-amino-4-methyl-phenyl)-propan-2-ol 
• 7664-93-9 sulfuric acid 
• 64-17-5 ethanol 
• 40267-59-2 thujone oxime 
• 10034-85-2 hydrogen iodide 
• 88-72-2 1-methyl-2-nitrobenzene 
• 2437-76-5 2-bromo-p-cymene 
• 31198-76-2 carvoxime 

Downstream Products

• 13540-91-5 5-isopropyl-2,N,N-trimethyl-aniline 
• 855699-76-2 N,N'-bis-(5-isopropyl-2-methyl-phenyl)-thiourea 
• 861555-17-1 (5-isopropyl-2-methyl-phenyl)-urea 
• 499-75-2 carvacrol 
• 56739-95-8 2-iodo-4-isopropyl-1-methylbenzene 
• 13540-92-6 acetic acid-(5-isopropyl-2-methyl-anilide) 
• 2437-39-0 2-isopropyl-5-methyl-phenylamine 
• 1079178-53-2 4-bromo-5-isopropyl-2-methylaniline 
• 4474-14-0 formic acid-(5-isopropyl-2-methyl-anilide) 
• 4395-79-3 2-chloro-p-cymene 
• 860405-03-4 bis-(4-amino-2-isopropyl-5-methyl-phenyl)-phenyl-methane 

Relevant academic research and scientific papers

Direct conversion of phenols into primary anilines with hydrazine catalyzed by palladium

Primary anilines are essential building blocks to synthesize various pharmaceuticals, agrochemicals, pigments, electronic materials, and others. To date, the syntheses of primary anilines mostly rely on the reduction of nitroarenes or the transition-metal-catalyzed Ullmann, Buchwald-Hartwig and Chan-Lam cross-coupling reactions with ammonia, in which non-renewable petroleum-based chemicals are typically used as feedstocks via multiple step syntheses. A long-standing scientific challenge is to synthesize various primary anilines directly from renewable sources. Herein, we report a general method to directly convert a broad range of phenols into the corresponding primary anilines with the cheap and widely available hydrazine as both amine and hydride sources with simple Pd/C as the catalyst.

Synthesis of N-aryl and N-heteroaryl hydroxylamines via partial reduction of nitroarenes with soluble nanoparticle catalysts

Polystyrene-supported ruthenium nanoparticles enable the selective hydrazine-mediated reduction of nitroarenes to hydroxylamine products in high yield and selectivity. Key to obtaining the hydroxylamine product in good yield was the use of organic solvents capable of solubilizing the polystyrene-supported nanoparticle catalyst. N-aryl and N-heteroaryl hydroxylamines are generated under exceptionally mild conditions and in the presence of a various easily reduced functional groups.

Reduction of 2-Nitro-p-cymene

Commercial 2-nitro-p-cymene has been carefully purified, and the following reduction products have been prepared: trans-2,2'-azo-p-cymene; 2,2'-hydrazo-p-cymene and its hydrochloride; 2-amino-p-cymene and its hydrochloride; and 2,2'-diisopropyl-5,5'-dimet