26190-82-9

Basic information

• Product Name: 2,5-Dimethylquinoline
• Synonyms: 2,5-Dimethylquinoline
• CAS NO: 26190-82-9
• Molecular Formula: C₁₁H₁₁N
• Molecular Weight: 157.21174
• Mol File: 26190-82-9.mol

Chemical Properties

• Melting Point: 61°C
• Boiling Point: 266.88°C (estimate)
• Appearance: /
• Density: 1.0491 (estimate)
• Refractive Index: 1.6106 (estimate)
• PKA: 6.05±0.50(Predicted)
• CAS DataBase Reference: 2,5-Dimethylquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-Dimethylquinoline(26190-82-9)
• EPA Substance Registry System: 2,5-Dimethylquinoline(26190-82-9)

Safety Data

• Hazardous Substances Data: 26190-82-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2,5-Dimethylquinoline is used as a building block in the synthesis of other chemicals for the production of pharmaceuticals. Its unique chemical structure makes it a promising candidate for the development of new drugs, particularly in the field of antimalarial and anticancer medications.
Used in Drug Development:
2,5-Dimethylquinoline is used as a key component in the development of new drugs, particularly for the treatment of malaria and cancer. Its unique chemical properties contribute to the effectiveness of these medications, making it an essential part of the drug development process.

Upstream product

• 123-73-9 trans-Crotonaldehyde 
• 108-44-1 1-amino-3-methylbenzene 
• 102-27-2 N-ethyl-m-toulidine 
• 64-17-5 ethanol 
• 107-21-1 ethylene glycol 
• 7664-93-9 sulfuric acid 
• 127-68-4 sodium 3-nitrobenzenesulfonate 
• 123-63-7 paracetaldehyde 
• 7647-01-0 hydrogenchloride 
• 75-07-0 acetaldehyde 
• 123-73-9 crotonaldehyde 

Downstream Products

• 103856-59-3 5-methyl-quinoline-2-carboxylic acid 
• 634-39-9 2-methyl-quinoline-5-carboxylic acid 

Relevant articles and documents

Photocatalytic Synthesis of Quinolines via Povarov Reaction under Oxidant-Free Conditions

We describe here an approach for synthesizing quinolines either from N-alkyl anilines or from anilines and aldehydes. A dual-catalyst system consisting of a photocatalyst and a proton reduction cocatalyst is employed. Without the use of any sacrificial ox

One-Pot Oxidative Synthesis of Substituted Quinolines from Alcohols and Arylamines Catalyzed by Fe(CrO2)2 in Water Medium

One-pot tandem synthesis was developed for substituted quinolines (in up to 97% yields) involving a selective catalytic oxidation of primary amines to aldehydes and their condensation with arylamines under the action of a dispersion of Fe(CrO2)2 and water solution of H2O2 at room temperature. The stage of catalytic oxidation of alcohols was accelerated by photoactivation. A presumable mechanism of the photoactivated tandem synthesis of 2-methylquinoline was suggested. Catalyst Fe(CrO2)2 was prepared by photochemical synthesis.

Fe(CrO2)2-catalyzed, photoactivated oxidative one-pot tandem synthesis of substituted quinolines from primary alcohols and arylamines

[Figure not available: see fulltext.] A one-pot tandem synthesis of substituted quinolines involving selective catalytic oxidation of primary alcohols to the corresponding aldehydes and their subsequent condensation with arylamines has been developed. Fe(CrO2)2 has been used as a catalyst, and oxidation has been performed with aqueous H2O2. To accelerate the catalytic oxidation of alcohols, photoactivation method has been applied.

Quinoline Synthesis by the Reaction of Anilines with 1,2-diols Catalyzed by Iron Compounds

The synthesis of quinoline derivatives by cyclocondensation of anilines with 1,2-ethanediol, 1,2-propanediol, and 1,2-butanediol in the presence of iron-containing catalysts was performed for the first time.

Doebner-miller synthesis in a two-phase system: Practical preparation of quinolines

Doebner-Miller cyclization was carried out in a two-phase solvent system. The method has shown to be advantageous to the yield and to the ease of the work-up process. (C) 2000 Elsevier Science Ltd.

The Rhodium Complex-catalyzed Synthesis of Quinolines from Aminoarenes and Aliphatic Aldehydes

A variety of aminoarenes react with aliphatic aldehydes in the presence of a catalytic amount of a rhodium complex and an excess amount of the corresponding nitroarenes at 180 deg C to give 2-alkyl- and 2,3-dialkyl-substituted quinolines in excellent yields.Among the rhodium complexes examined, 2 exhibits the highest activity as a catalyst.Thus, 2-methyl-, 2-ethyl-3-methyl-, 2-propyl-3-ethyl-, 2-butyl-3-propylquinoline derivatives are readily obtained from aminoarenes and ethanal, propanal, butanal, and pentanal respectively.