261920-64-3Relevant academic research and scientific papers
An efficient synthesis of a new series of acyclonucleosides starting from β-amino alcohols
Agami, Claude,Dechoux, Luc,Hamon, Louis,Melaimi, Mohand
, p. 6666 - 6669 (2000)
A series of new acyclonucleosides analogues 3 has been synthesized very efficiently in three steps starting from β-amino alcohols 1. The key step of this process is a nucleophilic substitution with various nucleophiles on 2,2'-anhydronucleosides 2. The chemo- and stereoselectivities of this reaction are discussed. AM1 calculations sustained the observed chemoselectivity.
