261958-59-2

Upstream product

• 2150-44-9 1-carbomethoxy-3,5-dihydroxybenzene 
• 76280-60-9 [3,5-bis(methoxymethoxy)phenyl]methanol 
• 76280-59-6 methyl 3,5-bis(methoxymethoxy)benzoate 
• 504-15-4 orcinol 
• 79834-15-4 (2-bromo-3,5-bis(methoxymethoxy)phenyl)methanol 
• 261958-58-1 4-{[2-benzyloxymethyl-6-methoxy-4-(methoxymethoxy)phenyl]hydroxymethyl}-3,5-bis(methoxymethoxy)-2,6-dichlorotoluene 
• 261958-54-7 2-benzyloxymethyl-4,6-bis(methoxymethoxy)benzaldehyde 
• 261958-53-6 2-benzyloxymethyl-4,6-bis(methoxymethoxy)bromobenzene 
• 261958-51-4 2-benzyloxymethyl-6-methoxy-4-(methoxymethoxy)benzaldehyde 
• 261958-56-9 2-benzyloxymethyl-6-hydroxy-4-(methoxymethoxy)benzaldehyde 
• 261958-52-5 3,5-bis(methoxymethoxy)-4-bromo-2,6-dichlorotoluene 
• 261958-55-8 2,4-dihydroxy-6-[(phenylmethoxy)methyl]-benzaldehyde 
• 261958-57-0 2-bromo-4,6-dichloro-5-methylbenzene-1,3-diol 
• 63992-61-0 4,6-dichloro-5-methylresorcinol 

Downstream Products

• 261958-60-5 2-[2,6-bis(methoxymethoxy)-3,5-dichloro-4-methylbenzoyl]-3-methoxy-5-(methoxymethoxy)benzyl alcohol 
• 261958-63-8 methyl 2-[2,6-bis(methoxymethoxy)-3,5-dichloro-4-methylbenzoyl]-3-methoxy-5-(methoxymethoxy)benzoate 
• 261958-62-7 2-(3,5-dichloro-2,6-bis-methoxymethoxy-4-methyl-benzoyl)-3-methoxy-5-methoxymethoxy-benzoic acid 
• 261958-61-6 2-[2,6-bis(methoxymethoxy)-3,5-dichloro-4-methylbenzoyl]-3-methoxy-5-(methoxymethoxy)benzaldehyde 
• 2151-16-8 methyl 2-(3,5-dichloro-2,6-dihydroxy-4-methylbenzoyl)-5-hydroxy-3-methoxybenzoate 

Relevant academic research and scientific papers

Synthetic studies on Sch 202596, an antagonist of the galanin receptor subtype GalR1: An efficient synthesis of (±)-geodin, the spirocoumaranone part of Sch 202596

An efficient and facile synthesis of (±)-geodin [(±)-2] corresponding to the spirocoumaranone part of Sch 202596 (1) was accomplished in a convergent manner. The synthetic method features (i) a coupling reaction of the aryl aldehyde 6 with the aryl lithium 7 generated in situ from the aryl bromide 8 to deliver the highly substituted diaryl methanol 24 (6+7→24) and ii) oxidative spirocyclization reaction of the benzophenone 4 to construct the requisite spirocoumaranone skeleton [4→(±)-2] as the key steps. The aromatic segments 6 and 8 were prepared from commercially available methyl 3,5-dihydroxybenzoate (9) and 5-methylresorcinol (10), respectively.

Studies toward the total synthesis of Sch 202596, an antagonist of the galanin receptor subtype GalR1: Synthesis of geodin, the spirocoumaranone subunit of Sch 202596

An efficient synthesis of (±)-geodin [(±)-2] corresponding to the spirocoumaranone subunit of Sch 202596 (1) was accomplished in a convergent manner by utilizing coupling reaction of the aryl aldehyde 5 with the aryl bromide 6 and oxidative spirocyclization of the benzophenone 4 as the key steps. The aromatic segments 5 and 6 were prepared from commercially available methyl 3,5-dihydroxybenzoate (7) and 5-methylresorcinol (8), respectively.