261958-62-7

Basic information

• Product Name: 2-(3,5-dichloro-2,6-bis-methoxymethoxy-4-methyl-benzoyl)-3-methoxy-5-methoxymethoxy-benzoic acid
• Synonyms: 2-(3,5-dichloro-2,6-bis-methoxymethoxy-4-methyl-benzoyl)-3-methoxy-5-methoxymethoxy-benzoic acid
• CAS NO: 261958-62-7
• Molecular Weight: 519.333
• Mol File: 261958-62-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(3,5-dichloro-2,6-bis-methoxymethoxy-4-methyl-benzoyl)-3-methoxy-5-methoxymethoxy-benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3,5-dichloro-2,6-bis-methoxymethoxy-4-methyl-benzoyl)-3-methoxy-5-methoxymethoxy-benzoic acid(261958-62-7)
• EPA Substance Registry System: 2-(3,5-dichloro-2,6-bis-methoxymethoxy-4-methyl-benzoyl)-3-methoxy-5-methoxymethoxy-benzoic acid(261958-62-7)

Safety Data

• Hazardous Substances Data: 261958-62-7(Hazardous Substances Data)

Upstream product

• 504-15-4 orcinol 
• 76280-59-6 methyl 3,5-bis(methoxymethoxy)benzoate 
• 76280-60-9 [3,5-bis(methoxymethoxy)phenyl]methanol 
• 79834-15-4 (2-bromo-3,5-bis(methoxymethoxy)phenyl)methanol 
• 63992-61-0 4,6-dichloro-5-methylresorcinol 
• 2150-44-9 1-carbomethoxy-3,5-dihydroxybenzene 
• 261958-61-6 2-[2,6-bis(methoxymethoxy)-3,5-dichloro-4-methylbenzoyl]-3-methoxy-5-(methoxymethoxy)benzaldehyde 
• 261958-58-1 4-{[2-benzyloxymethyl-6-methoxy-4-(methoxymethoxy)phenyl]hydroxymethyl}-3,5-bis(methoxymethoxy)-2,6-dichlorotoluene 
• 261958-59-2 2'-benzyloxymethyl-6'-methoxy-2,4',6-tris(methoxymethoxy)-3,5-dichloro-4-methylbenzophenone 
• 261958-60-5 2-[2,6-bis(methoxymethoxy)-3,5-dichloro-4-methylbenzoyl]-3-methoxy-5-(methoxymethoxy)benzyl alcohol 
• 261958-54-7 2-benzyloxymethyl-4,6-bis(methoxymethoxy)benzaldehyde 
• 261958-53-6 2-benzyloxymethyl-4,6-bis(methoxymethoxy)bromobenzene 
• 261958-51-4 2-benzyloxymethyl-6-methoxy-4-(methoxymethoxy)benzaldehyde 
• 261958-56-9 2-benzyloxymethyl-6-hydroxy-4-(methoxymethoxy)benzaldehyde 

Downstream Products

• 2151-16-8 methyl 2-(3,5-dichloro-2,6-dihydroxy-4-methylbenzoyl)-5-hydroxy-3-methoxybenzoate 
• 261958-63-8 methyl 2-[2,6-bis(methoxymethoxy)-3,5-dichloro-4-methylbenzoyl]-3-methoxy-5-(methoxymethoxy)benzoate 

Relevant articles and documents

Synthetic studies on Sch 202596, an antagonist of the galanin receptor subtype GalR1: An efficient synthesis of (±)-geodin, the spirocoumaranone part of Sch 202596

An efficient and facile synthesis of (±)-geodin [(±)-2] corresponding to the spirocoumaranone part of Sch 202596 (1) was accomplished in a convergent manner. The synthetic method features (i) a coupling reaction of the aryl aldehyde 6 with the aryl lithium 7 generated in situ from the aryl bromide 8 to deliver the highly substituted diaryl methanol 24 (6+7→24) and ii) oxidative spirocyclization reaction of the benzophenone 4 to construct the requisite spirocoumaranone skeleton [4→(±)-2] as the key steps. The aromatic segments 6 and 8 were prepared from commercially available methyl 3,5-dihydroxybenzoate (9) and 5-methylresorcinol (10), respectively.