261969-07-7Relevant academic research and scientific papers
Stereoselective glycosylation and oligosaccharide synthesis on solid support using a 4-azido-3-chlorobenzyl group for temporary protection
Egusa, Kenji,Fukase, Koichi,Nakai, Yoshihiko,Kusumoto, Shoichi
, p. 27 - 32 (2007/10/03)
A versatile and practical methodology for solid-phase synthesis was elaborated in the synthesis of α(1→6)- and β(1→6)linked oligoglucoses by using thioglycosides having a 4-azido-3-chlorobenzyl (ClAzb) group for temporary protection of hydroxy functions.
Azidohalogenobenzyl derivatives, sugar compounds and protection of hydroxy groups
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, (2008/06/13)
Azidohalogenobenzyl derivatives of the formula (I) STR1 wherein A is a halogen atom, B is a halogen atom or a hydrogen atom, and X is a group reactive with a hydroxy group, methods of protecting hydroxy group(s) using said derivatives, and sugar compounds wherein a hydrogen atom of at least one hydroxy group is substituted by an azidohalogenobenzyl group. According to the present invention, there are provided novel derivatives capable of introducing a group into a compound having hydroxy group(s), which group is useful as a stable hydroxy-protecting group even in solid phase synthesis for the purpose of the extension of sugar chain under continuous acidic conditions and of being removed under mild conditions; sugar compounds protected by using said derivatives; and methods of protecting hydroxy group(s) using said derivatives.
