26199-99-5

Upstream product

• 7259-53-2 4-benzylpyridine N-oxide 
• 1003-67-4 4-methylpyridine-1-oxide 
• 98-95-3 nitrobenzene 
• 100-00-5 4-chlorobenzonitrile 
• 1083-48-3 4-Nitrobenzylpyridin 
• 2116-65-6 4-benzyl pyridine 

Downstream Products

• 150223-65-7 4-(4-nitrobenzyl)pyridine-2-carbonitrile 
• 39055-88-4 (4-nitrophenyl)(pyridin-4-yl)methanone 
• 150223-71-5 di(tert-butyl) 2,2'-<<6-<4-<6-<amino>methyl>pyridin-2-yl>thiazol-2-yl>-4-(4-nitrobenzyl)pyridin-2-yl>methylimino>bis(acetate) 
• 150223-73-7 di(tert-butyl) 2,2'-<<4-(4-aminobenzyl)-6-<4-<6-<amino>methyl>pyridin-2-yl>thiazol-2-yl>pyridin-2-yl>methylimino>bis(acetate) 
• 150223-70-4 C-[6-[4-(6-Aminomethyl-pyridin-2-yl)-thiazol-2-yl]-4-(4-nitro-benzyl)-pyridin-2-yl]-methylamine 
• 150223-69-1 6-<4-(6-cyanopyridin-2-yl)thiazol-2-yl>-4-(4-nitrobenzyl)pyridine-2-carbonitrile 
• 150223-68-0 4-(4-nitrobenzyl)-2-<4-(pyridin-2-yl)thiazol-2-yl>pyridine N,N'-dioxide 
• 150223-67-9 4-(4-nitrobenzyl)-2-<4-(pyridin-2-yl)thiazol-2-yl>pyridine 
• 150223-66-8 4-(4-nitrobenzyl)pyridine-2-carbothioamide 

Relevant academic research and scientific papers

The M?CPbA?NH3(G) system: A safe and scalable alternative for the manufacture of (substituted) pyridine and quinoline N?oxides?

An improved, safe, and scalable isolation process for (substituted) pyridine and quinoline N-oxides in quantitative yields along with high purities using the m-CPBA?NH3(g) system is described. The safety was assessed by reaction calorimetry and differential scanning calorimetry studies for possible hazards during the conversion and isolation steps. Careful interpretation of the data substantiated the safety and scalability. The process flow is simplified to meet the industrial requirements of safety, cost-effectiveness, and utility minimization. The reaction was safely demonstrated at a 2.5 kg scale.

Oxidation reactions using polymer-supported 2-benzenesulfonyl-3-(4- nitrophenyl)oxaziridine

A thermally stable polymer-supported oxidant has been developed. Polymer-supported 2-benzenesulfonyl-3-(4-nitrophenyl)oxaziridine was applied to microwave-assisted reactions that occurred at high temperatures and was shown to oxidize alkenes, silyl enol ethers, and pyridines to the corresponding epoxides and pyridine N-oxides in excellent to good yields and with much shorter reaction times. It also enabled tetrahydrobenzimidazoles to be oxidatively rearranged to spiro fused 5-imidazolones in a more efficient manner. Recycling of the polymer-supported oxidant is also possible with minimal loss of activity after several reoxidations.

28. Novel thiazole-containing complexing agents and luminescence of their europium(III) and terbium(III) chelates

The synthesis of novel thiazole-containing complexing agents and their luminescence properties with EuIII and TbIII ions are reported. One of these terpyridine analogues was also tested as an EuIII labelling reagent, and its luminescence properties as an antibody conjugate were studied.

Luminescent lanthanide chelates

Lanthanide chelates which contain three heterocyclic rings covalently coupled to each other (either one 2,6-pyridylene and two five-membered unsaturated heterocyclic ring moieties or two 2,6-pyridylene and one five-membered unsaturated heterocyclic ring moiety) and two chelating groups so seated that they together chelate the same lanthanide ion even in aqueous solutions. These lanthanide chelates can optionally contain a reactive group for coupling to biologically active molecules. The new chelates are suitable for classical lanthanide chelate applications and are also useful as probes in time-resolved fluorescence microscopy, cytometry, multilabelling techniques and in process controls in industry.