26213-36-5Relevant academic research and scientific papers
Ionophoric polyphenols selectively bind Cu2+, display potent antioxidant and anti-amyloidogenic properties, and are non-toxic toward Tetrahymena thermophila
Martínez, Alberto,Alcendor, Ralph,Rahman, Tanzeen,Podgorny, Magdalena,Sanogo, Ismaila,McCurdy, Rebecca
, p. 3657 - 3670 (2016)
Alzheimer's disease (AD) is the most common form of dementia affecting more than 28 million people in the world. Only symptomatic treatments are currently available. Anticipated tri-fold increase of AD incidence in the next 50 years has established the ne
The scavenging of DPPH, galvinoxyl and ABTS radicals by imine analogs of resveratrol
Kotora, Peter,?er?ěn, Franti?ek,Filo, Juraj,Loos, Du?an,Gregáň, Juraj,Gregáň, Fridrich
, (2016/02/05)
Resveratrol (3,5,41-trihydroxystilbene) is a phytoalexin produced by plants. Resveratrol is known for its anti-cancer, antiviral and antioxidant properties. We prepared imine analogs of resveratrol ((hydroxyphenyliminomethyl)phenols) and tested their anti
Design, synthesis and biological evaluation of imine resveratrol derivatives as multi-targeted agents against Alzheimer's disease
Li, Su-Yi,Wang, Xiao-Bing,Kong, Ling-Yi
, p. 36 - 45 (2013/12/04)
A series of imine resveratrol derivatives (1-20) have been designed, synthesized, and evaluated as multi-targeted compounds for the treatment of Alzheimer's disease (AD). In vitro studies show that most of the molecules exhibit a significant ability to in
The antioxidant effect of imine resveratrol analogues
Lu, Jing,Li, Chang,Chai, Yun-Feng,Yang, De-Yu,Sun, Cui-Rong
supporting information; experimental part, p. 5744 - 5747 (2012/09/22)
Twenty five Imine resveratrol analogues (IRAs) were synthesized, replacing the CC bond in resveratrol with CN bond, as well as substitution modifications on aromatic rings. Radical scavenging activities against DPPH, along with singlet oxygen quenching capacities were evaluated, and further confirmed using density functional theory calculations (DFT). It was found that IRAs bearing ortho-OH on B ring have better radical scavenging activities against DPPH than resveratrol, these compounds were also found to be effective 1O 2 quenchers. Theoretical studies on the reaction mechanism of these compounds with 1O2 suggest that the 1,3-addition to a double bond with a -OH group with the formation of allylic hydroperoxide is the most probable reaction route.
Benzylideneaniline derivatives
-
, (2008/06/13)
This invention describes a method of treating inflammation in warm blooded animals by topically administering an effective amount of benzylideneaniline or its derivatives.
