3164-06-5

Basic information

• Product Name: 3-(Benzo[d]oxazol-2-yl)phenol
• Synonyms: 3-(Benzo[d]oxazol-2-yl)phenol;2-(3'-hydroxyphenyl)benzothiazole
• CAS NO: 3164-06-5
• Molecular Formula: C₁₃H₉NO₂
• Molecular Weight: 211.21606
• Mol File: 3164-06-5.mol
• Article Data: 19

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-(Benzo[d]oxazol-2-yl)phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(Benzo[d]oxazol-2-yl)phenol(3164-06-5)
• EPA Substance Registry System: 3-(Benzo[d]oxazol-2-yl)phenol(3164-06-5)

Safety Data

• Hazardous Substances Data: 3164-06-5(Hazardous Substances Data)

Upstream product

• 99-06-9 3-Carboxyphenol 
• 95-55-6 2-amino-phenol 
• 26213-36-5 3-Hydroxy-benzaldehyd-<2-hydroxy-phenylimin> 
• 100-83-4 meta-hydroxybenzaldehyde 
• 620-24-6 3-Hydroxybenzyl alcohol 
• 273-53-0 benzoxazole 
• 626-02-8 3-Iodophenol 
• 615-18-9 2-chloro-1,3-benzoxazole 
• 10365-98-7 3-methoxyphenylboronic acid 
• 32959-59-4 2-(3-methoxyphenyl)benzoxazole 
• 41373-36-8 2-(3-hydroxyphenyl)benzothiazole 
• 840-56-2 2-(3-nitrophenyl)benzoxazole 
• 5348-26-5 3-nitrobenzylidene-2-aminophenol 
• 99-61-6 3-nitro-benzaldehyde 

Downstream Products

• 1334551-94-8 2-(3-(3-bromopropoxy)phenyl)benzo[d]oxazole 
• 1188498-83-0 3-(benzo[d]oxazol-2-yl)phenyl propylcarbamate 
• 32959-59-4 2-(3-methoxyphenyl)benzoxazole 

Relevant articles and documents

A rapid method for the preparation of 2-substituted oxazolo[4,5-b]pyridines using microwave-assisted direct condensation reactions

The condensation reaction of 2-amino-3-hydroxypyridine with different carboxylic acids by microwave-assisted heating is a fast method for producing libraries based on fused 2-substituted oxazolo[4,5-b]pyridines in moderate to good yields.

2-Aryl benzazole derived new class of anti-tubercular compounds: Endowed to eradicate mycobacterium tuberculosis in replicating and non-replicating forms

The high mortality rate and the increasing prevalence of Mtb resistance are the major concerns for the Tuberculosis (TB) treatment in this century. To counteract the prevalence of Mtb resistance, we have synthesized 2-aryl benzazole based dual targeted molecules. Compound 9m and 9n were found to be equally active against replicating and non-replicating form of Mtb (MIC(MABA) 1.98 and 1.66 μg/ml; MIC(LORA) 2.06 and 1.59 μg/ml respectively). They arrested the cell division (replicating Mtb) by inhibiting the GTPase activity of FtsZ with IC50 values 45 and 64 μM respectively. They were also capable of kill Mtb in non-replicating form by inhibiting the biosynthesis of menaquinone which was substantiated by the MenG inhibition (IC50 = 11.62 and 7.49 μM respectively) followed by the Vit-K2 rescue study and ATP production assay.

One-pot green synthesis of benzoxazole derivatives through molecular sieve-catalyzed oxidative cyclization reaction

An one-pot approach to benzoxazole ring from 2-aminophenol and aldehydes utilizing molecular sieve as the catalyst have been developed. The new oxidative cyclization reaction excluded the usage of hazardous chemical reagents, transition-metal catalysts, chemical oxidants, or strong acids, and, therefore, reduced the production of toxic chemical waste. This offers an environmentally friendly pathway for the synthesis of various benzoxazole derivatives.