262375-99-5

Basic information

• Product Name: [4-(4-AMINO-PHENYL)-PIPERAZIN-1-YL]-PHENYL-METHANONE
• Synonyms: TIMTEC-BB SBB009821;ASISCHEM Z44350;ART-CHEM-BB B025575;AKOS BB-8550;[4-(4-AMINO-PHENYL)-PIPERAZIN-1-YL]-PHENYL-METHANONE;4-(4-benzoylpiperazin-1-yl)aniline;[4-(4-aminophenyl)-1-piperazinyl]-phenylmethanone;[4-(4-benzoylpiperazin-1-yl)phenyl]amine
• CAS NO: 262375-99-5
• Molecular Formula: C₁₇H₁₉N₃O
• Molecular Weight: 281.35
• Mol File: 262375-99-5.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: [4-(4-AMINO-PHENYL)-PIPERAZIN-1-YL]-PHENYL-METHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: [4-(4-AMINO-PHENYL)-PIPERAZIN-1-YL]-PHENYL-METHANONE(262375-99-5)
• EPA Substance Registry System: [4-(4-AMINO-PHENYL)-PIPERAZIN-1-YL]-PHENYL-METHANONE(262375-99-5)

Safety Data

• Hazardous Substances Data: 262375-99-5(Hazardous Substances Data)

Usage

General Description

[4-(4-amino-phenyl)-piperazin-1-yl]-phenyl-methanone, also known as 4-(4-aminophenyl)piperazin-1-yl)phenylmethanone, is a chemical compound with a molecular formula of C17H19N3O. It is a piperazine derivative that is commonly used in the development and research of pharmaceutical drugs, particularly in the field of neuroscience and psychiatric disorders. [4-(4-amino-phenyl)-piperazin-1-yl]-phenyl-methanone has been studied for its potential as a serotonin modulator, and it may have applications in the treatment of mood disorders, anxiety, and depression. Additionally, it has been investigated for its potential antipsychotic and analgesic properties. The chemical structure and properties of [4-(4-amino-phenyl)-piperazin-1-yl]-phenyl-methanone make it a promising candidate for further research and development in the pharmaceutical industry.

Upstream product

• 6269-89-2 1-(4-Nitrophenyl)piperazine 
• 182618-86-6 tert-butyl 4-(4-nitrophenyl)piperazine-1-carboxylate 
• 350-46-9 4-Fluoronitrobenzene 
• 636-98-6 p-nitrobenzene iodide 
• 13754-38-6 N-Benzoylpiperazine 
• 16324-55-3 [4-(4-nitro-phenyl)-piperazin-1-yl]-phenyl-methanone 

Downstream Products

• 1594853-50-5 (4-(4-(6-chloro-2-methoxyacridin-9-ylamino)phenyl)piperazin-1-yl)(cyclohexyl)methanone 
• 857580-95-1 N-(4-(4-benzoylpiperazin-1-yl)phenyl)benzamide 

Relevant articles and documents

Phenylpiperazine type UBE2F small molecule inhibitor and synthesis method thereof

The invention discloses a phenylpiperazine type UBE2F small molecule inhibitor and a synthesis method thereof, discloses a phenylpiperazine type compound represented by the general formula I or a pharmaceutically acceptable salt thereof, and further discloses a synthesis route of the general formula I and a synthesis method of each step. As a small molecule inhibitor target at UBE2F, that phenylpiperazine type compound of the present invention effectively suppresses the growth of tumor cell by preventing the G2/M process of cell cycle and inducing apoptosis of human tumor cells. Therefore, thecompound is a new class of specific anti-tumor drugs by targeting UBE2F.

Functionalized acridin-9-yl phenylamines protected neuronal HT22 cells from glutamate-induced cell death by reducing intracellular levels of free radical species

The in vitro neuronal cell death model based on the HT22 mouse hippocampal cell model is a convenient means of identifying compounds that protect against oxidative glutamate toxicity which plays a role in the development of certain neurodegenerative diseases. Functionalized acridin-9-yl-phenylamines were found to protect HT22 cells from glutamate challenge at submicromolar concentrations. The Aryl1-NHAryl2 scaffold that is embedded in these compounds was the minimal pharmacophore for activity. Mechanistically, protection against the endogenous oxidative stress generated by glutamate did not involve up-regulation of glutathione levels but attenuation of the late stage increases in mitochondrial ROS and intracellular calcium levels. The NH residue in the pharmacophore played a crucial role in this regard as seen from the loss of neuroprotection when it was structurally modified or replaced. That the same NH was essential for radical scavenging in cell-free and cell-based systems pointed to an antioxidant basis for the neuroprotective activities of these compounds.