857580-95-1

Upstream product

• 262375-99-5 [4-(4-amino-phenyl)-piperazin-1-yl]-phenyl-methanone 
• 65-85-0 benzoic acid 
• 350-46-9 4-Fluoronitrobenzene 
• 182618-86-6 tert-butyl 4-(4-nitrophenyl)piperazine-1-carboxylate 
• 6269-89-2 1-(4-Nitrophenyl)piperazine 
• 16324-55-3 [4-(4-nitro-phenyl)-piperazin-1-yl]-phenyl-methanone 

Relevant academic research and scientific papers

Phenylpiperazine type UBE2F small molecule inhibitor and synthesis method thereof

The invention discloses a phenylpiperazine type UBE2F small molecule inhibitor and a synthesis method thereof, discloses a phenylpiperazine type compound represented by the general formula I or a pharmaceutically acceptable salt thereof, and further discloses a synthesis route of the general formula I and a synthesis method of each step. As a small molecule inhibitor target at UBE2F, that phenylpiperazine type compound of the present invention effectively suppresses the growth of tumor cell by preventing the G2/M process of cell cycle and inducing apoptosis of human tumor cells. Therefore, thecompound is a new class of specific anti-tumor drugs by targeting UBE2F.