26239-24-7

Upstream product

• 556-90-1 pseudothiohydantoin 
• 98-88-4 benzoyl chloride 

Downstream Products

• 56745-46-1 2-benzoylamino-5-(Z)-furfurylidene-thiazol-4-one 
• 56745-43-8 2-benzoylamino-5-(3-nitro-benzylidene)-thiazol-4-one 
• 56745-42-7 2-benzoylamino-5-(4-nitro-benzylidene)-thiazol-4-one 
• 56745-45-0 2-benzoylamino-5-{4-[bis-(2-chloro-ethyl)-amino]-benzylidene}-thiazol-4-one 

Relevant academic research and scientific papers

Synthesis of new phenolic compounds and biological evaluation as antiproliferative agents

New series of phenolic azomethine compounds in addition to 5-arylidene thiazolidinones are synthesized and screened for their anticancer activity against the brain cancer cell line SNB-75 and non-small lung cancer cells HOP-92. The azomethine derivative 12b is the most active compound against SNB-75 displaying an IC50 value of 0.14 μM. Compounds 7b, 16a and 27d display submicromolar activity against the HOP-92 cell line with IC50 values of 0.73, 0.74 and 0.81 μM, respectively. Moreover, studying the cytotoxic effects of the most active compounds against normal lung cells WI-38 revealed that compounds 7b, 16a and 27d showed high safety profiles as anticancer agents.