2627-53-4

Basic information

• Product Name: 2-(methylsulfanyl)-4-(thiophen-2-yl)-6-(trifluoromethyl)pyrimidine
• Synonyms: 2-(Methylsulfanyl)-4-(2-thienyl)-6-(trifluoromethyl)pyrimidine; pyrimidine, 2-(methylthio)-4-(2-thienyl)-6-(trifluoromethyl)-
• CAS NO: 2627-53-4
• Molecular Formula: C₁₀H₇F₃N₂S₂
• Molecular Weight: 276.3012
• Mol File: 2627-53-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 365.7°C at 760 mmHg
• Flash Point: 175°C
• Density: 1.46g/cm³
• Vapor Pressure: 3.24E-05mmHg at 25°C
• Refractive Index: 1.582
• CAS DataBase Reference: 2-(methylsulfanyl)-4-(thiophen-2-yl)-6-(trifluoromethyl)pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(methylsulfanyl)-4-(thiophen-2-yl)-6-(trifluoromethyl)pyrimidine(2627-53-4)
• EPA Substance Registry System: 2-(methylsulfanyl)-4-(thiophen-2-yl)-6-(trifluoromethyl)pyrimidine(2627-53-4)

Safety Data

• Hazardous Substances Data: 2627-53-4(Hazardous Substances Data)

Usage

General Description

2-(methylsulfanyl)-4-(thiophen-2-yl)-6-(trifluoromethyl)pyrimidine is a chemical compound with a molecular formula C11H8F3N3S. It is a pyrimidine derivative with a methylsulfanyl group attached to the 2 position, a thiophen-2-yl group attached to the 4 position, and a trifluoromethyl group attached to the 6 position. 2-(methylsulfanyl)-4-(thiophen-2-yl)-6-(trifluoromethyl)pyrimidine has potential applications in pharmaceutical research and drug development, as pyrimidine derivatives are known to possess a wide range of biological activities. Additionally, the presence of the trifluoromethyl group may impart unique physicochemical properties to the compound, making it a potentially valuable building block for the synthesis of new materials or bioactive compounds.

Upstream product

• 867-44-7 S-Methylisothiourea sulfate 
• 66180-39-0 3-hydroxy-1-(thiophen-2-yl)-4,4,4-trifluorobut-2-en-1-one 
• 88-15-3 2-Acetylthiophene 
• 326-91-0 1,1,1-trifluoro-4-(2-thienyl)butane-2,4-dione 
• 398996-45-7 6-(2-thienyl)-4-(trifluoromethyl)pyrimidine-2-(1H)-thione 
• 74-88-4 methyl iodide 
• 398996-45-7 6-(2-thienyl)-4-(trifluoromethyl)pyrimidine-2(1H)-thione 

Downstream Products

• 1217817-56-5 N,N-dimethyl-4-[4-(2-thienyl)-6-(trifluoromethyl)pyrimidin-2-yl]aniline 

Relevant articles and documents

APOPTOSIS INHIBITORS

The invention provides compounds that are inhibitors or covalent modifiers of succinate dehydrogenase subunit B (SDHB) and/or inhibitors of apoptosis, and pharmaceutically acceptable salts, hydrides and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition.

Pd- and Ni-catalyzed cross-coupling reactions of functionalized organozinc reagents with unsaturated thioethers

A variety of unsaturated thioethers have been subjected to cross-coupling reactions with functionalized zinc reagents in the presence of a transition-metal catalyst. Three different catalytic systems based on Pd(OAc)2 or [Ni(acac)2] and the ligands S-Phos or DPE-Phos gave the best results. N-Heterocyclic thioethers based on a pyridine, pyrimidine, pyrazine, pyridazine, triazine, benzothiazole, benzoxazole, pyrrole, or quinazoline ring, as well as thiomethylacetylenes, serve as electrophiles in this cross-coupling reaction. Aryl-, heteroaryl-, benzylic, and alkylzinc halides with sensitive functionalities, such as ester, nitrile, or ketone groups react at ambient temperature with unsaturated thioethers using a Ni catalyst. The corresponding Pd-catalyzed reactions require slightly higher temperatures. Large-scale cross-coupling experiments (10-20 mmol) with N-heterocycles are also reported.

Antimycotic drugs. 5th Communication: carbocyclically and heterocyclically substituted trifluoromethylpyrimidines

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