71508-05-9Relevant academic research and scientific papers
Shorter puromycin analog synthesis by means of an efficient Staudinger-Vilarrasa coupling
Chapuis, Hubert,Strazewski, Peter
, p. 12108 - 12115 (2006)
An efficient Staudinger-Vilarrasa coupling generates amides from azides and 1-hydroxybenzotriazole esters of amino- or hydroxy acid derivatives in very high isolated yields and purity. New puromycin analogs, mostly putative biosynthetic intermediates, wer
A practical route to 3′-amino-3′-deoxyadenosine derivatives and puromycin analogues
Nguyen-Trung, Nhat Quang,Botta, Oliver,Terenzi, Silvia,Strazewski, Peter
, p. 2038 - 2041 (2003)
3′-Aminoacylamino-3′-deoxyadenosines, analogues of the antibiotic puromycin, have been synthesized from adenosine. They key 3′-azido derivative 10 was obtained through a 3′-oxidation/reduction/substitution procedure. A modified purification protocol on a
High-yield immobilization of a puromycin analogue for the solid support synthesis of aminoacyl-tRNA fragments
Nguyen-Trung, Nhat Quang,Terenzi, Silvia,Scherer, Gerd,Strazewski, Peter
, p. 2603 - 2606 (2003)
(Matrix presented) An efficient procedure for the immobilization of 3′-deoxy-3′-(O-methyltyrosyl)aminoadenosine was developed. A poly(ethylene glycol)-derived diacid linker/spacer was attached to aminomethyl polystyrene. Coupling of the 2′-hydroxy instead
The shortest synthetic route to puromycin analogues using a modified robins approach
Krishnakumar, Kollappillil S.,Goudedranche, Sebastien,Bouchu, Denis,Strazewski, Peter
, p. 2253 - 2256 (2011/05/30)
We are reporting on the utility of commercial vinyl isocyanate for a practical synthetic route from adenosine to N6-bis-demethylpuromycin in seven steps and 65% overall yield. A clean one-pot conversion of 3′-bromo-2′-carbamoyl derivative 8 to
Facile and rapid access to inosine puromycin analogues through the use of adenylate deaminase
Charafeddine, Adib,Chapuis, Hubert,Strazewski, Peter
, p. 2787 - 2790 (2008/02/05)
To study the ribosomal peptidyl transfer, puromycin analogues are of interest in which adenine has been replaced by hypoxanthine. We synthesized inosine puromycin analogues from 3′-azidodeoxyadenosine derivatives using adenylate deaminase for the quantita
