2627-77-2

Usage

Uses

Used in Pharmaceutical Industry:
4'-Bromosalicylanilide is used as an intermediate in the synthesis of various pharmaceuticals for its ability to be a building block in the manufacturing of drugs. Its presence in the molecular structure of certain drugs contributes to their therapeutic properties.
Used in Dye Industry:
4'-Bromosalicylanilide is used as an intermediate in the synthesis of dyes for its role in creating pigments that impart color to various materials. Its chemical structure allows for the development of dyes with specific color characteristics.
Used in Medicinal Chemistry Research:
4'-Bromosalicylanilide is used as a subject of study in medicinal chemistry for its potential biological activities, such as anti-inflammatory and antimicrobial properties. This research aims to explore its therapeutic potential and possibly develop new drugs based on its chemical structure.
Overall, 4'-Bromosalicylanilide is a multifaceted compound with applications in different industries, including pharmaceuticals, dyes, and medicinal chemistry research, due to its unique chemical properties and potential for biological activity.

Upstream product

• 106-40-1 4-bromo-aniline 
• 1441-87-8 salicyloyl chloride 
• 69-72-7 salicylic acid 

Downstream Products

• 13563-07-0 3-(4-Bromophenyl)-2H-1,3-benzoxazine-2,4(3H)-dione 
• 28534-34-1 3-(4-bromo-phenyl)-2-methoxycarbonylmethyl-4-oxo-3,4-dihydro-2H-benzo[e][1,3]oxazine-2-carboxylic acid methyl ester 
• 1321192-29-3 10-(4-bromophenyl)-7-nitrodibenzo[ b,f][1,4]oxazepin-11-(10H)-one 
• 1369423-70-0 11-(4-bromophenyl)-3-(tetrahydro-2H-pyran-2-yl)benzo[f]pyridazino[4,5-b][1,4]oxazepine-4,10(3H,11H)-dione 

Relevant academic research and scientific papers

One-pot synthesis of salicylanilides by direct amide bond formation from salicyclic acid under microwave irradiation

A highly efficient protocol for the preparation of aromatic amides is described by the direct reactions between salicyclic acid and aromatic amines in the presence of phosphorous trichloride under microwave irradiation. The method has several advantages over the conventional methods, including operational simplicity, good yield, and reduced reaction time.

Synthesis and antiproliferative activities against Hep-G2 of salicylanide derivatives: Potent inhibitors of the epidermal growth factor receptor (EGFR) tyrosine kinase

A series of salicylanilide derivatives (compounds 1-32) were synthesised by reacting substituted salicylic acids and anilines. The chemical structures of these compounds were determined by 1H-NMR, electrospray ionisation mass spectrometry (ESI-MS) and elemental analysis. The compounds were assayed for their antiproliferative activities against the Hep-G2 cell line by the 3-(4,5-dimethylthylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method. Among the compounds tested, 22 and 28 showed the most favouable antiproliferative activities with 50% inhibitory concentration (IC50) values of 1.7 and 1.3 μM, respectively, which were comparable to the positive control of 5-fluorouracil (IC50 = 1.8 μM). A solid-phase ELISA assay was also performed to evaluate the ability of compounds 1-32 to inhibit the autophosphorylation of the epidermal growth factor receptor tyrosine kinase (EGFR TK). Docking simulations of 22 and 28 were carried out to illustrate the binding mode of the molecule into the EGFR active site, and the result suggested that both compounds 22 and 28 could bind the EGFR kinase well.