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Usage

Uses

Used in Pharmaceutical Industry:
2 H-Pyrazole-3-carboxylic acid hydrazide is used as a precursor in the synthesis of various drugs, contributing to the development of new therapeutic agents.
Used in Agrochemicals:
In the agrochemical industry, 2 H-Pyrazole-3-carboxylic acid hydrazide is used in the synthesis of compounds that help protect crops from pests and diseases, leveraging its antifungal properties.
Used in Organic Synthesis:
As a building block in organic synthesis, 2 H-Pyrazole-3-carboxylic acid hydrazide is employed to create a variety of complex organic molecules for different applications, including the development of new materials and compounds.
Used in Analytical Techniques:
2 H-Pyrazole-3-carboxylic acid hydrazide is utilized in the development of analytical techniques for the detection and quantification of various chemical compounds, enhancing the accuracy and efficiency of chemical analysis in research and industry.

Upstream product

• 15366-34-4 methyl 1H-pyrazole-3-carboxylate 
• 15366-34-4 methyl 1H-pyrazole 3-carboxylate 

Downstream Products

• 109592-72-5 3-phenyl-3-(1⁽²⁾H-pyrazole-3-carbonylhydrazono)-propionic acid ethyl ester 
• 56976-88-6 dihydro-1,2 oxo-1 pyrazolo<1,5-d>triazine-1,2,4 
• 122-51-0 orthoformic acid triethyl ester 
• 119073-82-4 5-(1(2)H-pyrazol-3-yl)-3H-[1,3,4]oxadiazole-2-thione 
• 69081-08-9 ethyl 4,6-dimethyl-2-methylaminopyridine-3-carboxylate 
• 26911-66-0 2-hydroxy-5,7-dimethylpyrazolo(1,5-a)-pyrimidine 

Relevant academic research and scientific papers

Synthesis of N- and C-azolyl-substituted pyrazolo[1,5-a]pyrimidines by recyclization of pyrimidinium salts

We studied the reaction of 2-(ethoxycarbonyl)methyl-1,4,6-trimethylpyrimidinium iodide with hydrazides of N-azolyl- and C-pyrazolyl-substituted carboxylic acids, which were synthesized by reacting the respective esters with hydrazine hydrate. This reaction was shown to result in recyclization and formation of ethyl 2-(pyrazolylalkyl)- and 2-(azolylalkyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidine- 3-carboxylates. Besides pyrazolopyrimidines, the separation of reaction mixture provided in some cases also another recyclization product, 2-hydroxy-5,7-dimethylpyrazolo[1,5-a]pyrimidine.

P38 KINASE INHIBITING AGENTS

Compounds described by the chemical formula (I) or pharmaceutically acceptable salts thereof: Formula (I); are inhibitors of p38 and are useful in the treatment of inflammation such as in the treatment of asthma, COPD, ARDS, rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, gouty arthritis and other arthritic conditions; inflamed joints, eczema, psoriasis or other inflammatory skin conditions such as sunburn; inflammatory eye conditions including conjunctivitis; pyresis, pain and other conditions associated with inflammation.