26293-59-4

Upstream product

• 34311-63-2 5-O-benzyl-3-oxo-1,2-O-isopropylidene-α-D-xylofuranose 
• 19493-09-5 Methylenetriphenylphosphorane 
• 109-72-8 n-butyllithium 
• 1779-49-3 Methyltriphenylphosphonium bromide 
• 6893-65-8 1,2-di-O-isopropylidene-5-O-tosyl-D-xylofuranose 
• 20031-21-4 1,2-O-isopropylidene-α-D-xylose 
• 23202-83-7 5-benzyl-1,2-O-isopropylidene-α-D-xylofuranose 

Downstream Products

• 34311-67-6 3-deoxy-3-(hydroxymethyl)-1,2-O-(1-methylethylidene)-5-O-(phenylmethyl)-α-D-ribofuranose 
• 69827-91-4 3-deoxy-1,2-O-(1-methylethylidene)-3-<(phenylmethoxy)methyl>-5-O-(phenylmethyl)-α-D-ribofuranose 
• 1026404-30-7 (3R,4S,5S)-4,5-Bis-benzyloxymethyl-tetrahydro-furan-2,3-diol 
• 132523-62-7 3-deoxy-3-<(phenylmethoxy)methyl>-5-O-(phenylmethyl)-α-D-ribofuranose diacetate 

Relevant academic research and scientific papers

Strategy for the preparation of 2' and 3' branched nucleosides

1-(5-O-Benzyl-3-C-methylidene-2-oxo-3-deoxy-β-D-glycero-pentofuranosyl) thymine was prepared as the precursor of 2',3'-dibranched nucleosides in six steps from 5-O-benzyl-1,2-O-isopropylidene-α-D-xylofuranose. This enone is the key starting compound for the preparation of a large series of potential antiretroviral agents against HIV-1.

Synthesis and antiviral activity of novel isonucleoside analogs

A series of branched-chain sugar isonucleosides was synthesized and evaluated for antiviral activity against herpesviruses. The preparation of homochiral [3S-(3α,4β,5α)]-2-amino-1,9-dihydro-9-[tetrahydro-4,5- bis(hydroxymethyl)-3-furanyl]-6H-purin-6-one (