34311-67-6Relevant articles and documents
Synthesis and antiviral activity of novel isonucleoside analogs
Tino,Clark,Field,Jacobs,Lis,Michalik,McGeever-Rubin,Slusarchyk,Spergel,Sundeen,Tuomari,Weaver,Young,Zahler
, p. 1221 - 1229 (1993)
A series of branched-chain sugar isonucleosides was synthesized and evaluated for antiviral activity against herpesviruses. The preparation of homochiral [3S-(3α,4β,5α)]-2-amino-1,9-dihydro-9-[tetrahydro-4,5- bis(hydroxymethyl)-3-furanyl]-6H-purin-6-one (
3′-C-branched-chain-substituted nucleosides and nucleotides as potent inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase
Vanheusden, Veerle,Munier-Lehmann, Hélène,Froeyen, Matheus,Dugué, Laurence,Heyerick, Arne,De Keukeleire, Denis,Pochet, Sylvie,Busson, Roger,Herdewijn, Piet,Van Calenbergh, Serge
, p. 3811 - 3821 (2007/10/03)
Thymidine monophosphate kinase (TMPK) of Mycobacterium tuberculosis (TMPKmt) represents an attractive target for blocking the bacterial DNA synthesis. In an attempt to find high-affinity inhibitors of TMPKmt, a cavity in the enzyme at the 3′-position was
Purinyl tetrahydrofurans
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, (2008/06/13)
Antiviral activity is exhibited by compounds having the formula STR1 and pharmaceutically acceptable salts thereof wherein R1 is a purine or pyrimidine base or an analog thereof and R2 and R3 are independently hydrogen, --