263009-02-5

Basic information

• Product Name: 2'-O-[1-(4-Chlorophenyl)-4-ethoxypiperidin-4-yl]cytidine
• Synonyms: 2'-O-[1-(4-Chlorophenyl)-4-ethoxypiperidin-4-yl]cytidine
• CAS NO: 263009-02-5
• Molecular Weight: 480.948
• Mol File: 263009-02-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2'-O-[1-(4-Chlorophenyl)-4-ethoxypiperidin-4-yl]cytidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-O-[1-(4-Chlorophenyl)-4-ethoxypiperidin-4-yl]cytidine(263009-02-5)
• EPA Substance Registry System: 2'-O-[1-(4-Chlorophenyl)-4-ethoxypiperidin-4-yl]cytidine(263009-02-5)

Safety Data

• Hazardous Substances Data: 263009-02-5(Hazardous Substances Data)

Upstream product

• 908140-96-5 N-(1-{(2R,3R,3aR,9aR)-3-[1-(4-Chloro-phenyl)-4-ethoxy-piperidin-4-yloxy]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl}-2-oxo-1,2-dihydro-pyrimidin-4-yl)-benzamide 
• 3592-25-4 1,5-dichloropentan-3-one 
• 263009-01-4 4-N-Benzoyl-2'-O-[1-(4-chlorophenyl)-4-ethoxypiperidin-4-yl]cytidine 
• 263008-89-5 1-(4-Chlorophenyl)-4,4-diethoxypiperidine 
• 263008-90-8 1-(4-Chlorophenyl)-4-ethoxy-1,2,5,6-tetrahydropyridine 
• 113759-96-9 1-(4-chlorophenyl)piperidin-4-one 
• 119836-12-3 4-hydroxy-1-(4-chlorophenyl)piperidine 
• 106-47-8 4-chloro-aniline 
• 72548-31-3 1,5-Dichloropentan-3-ol 

Downstream Products

• 113759-96-9 1-(4-chlorophenyl)piperidin-4-one 
• 65-46-3 CYTIDINE 

Relevant articles and documents

Some observations relating to the use of 1-aryl-4-alkoxypiperidin-4-yl groups for the protection of the 2′-hydroxy functions in the chemical synthesis of oligoribonucleotides

The comparative rates of acid-catalysed removal often 1-aryl-4-methoxypiperidin-4-yl 8 (R = Me) [including the previously reported Ctmp 5 and Fpmp 6] protecting groups for the 2′-hydroxy functions in oligoribonucleotide synthesis are discussed. These studies have led to the development of the 1-(4-chlorophenyl)-4-ethoxypiperidin-4-yl (Cpep) protecting group 8 (R = Et, R1 = R2 = H, R3 = Cl) which is both more stable than the Ctmp and Fpmp groups at pH 0.5 and more labile at pH 3.75. The influence of the ribonucleoside aglycone on the stability of the 2′-O-Fpmp and 2′-O-Ctmp protecting groups both at low and high pH is examined. The Royal Society of Chemistry 2000.