113759-96-9

Basic information

• Product Name: 1-(4-CHLORO-PHENYL)-PIPERIDIN-4-ONE
• Synonyms: CHEMBRDG-BB 4000323;1-(4-CHLORO-PHENYL)-PIPERIDIN-4-ONE;4-piperidinone, 1-(4-chlorophenyl)-;1-(4-chlorophenyl)piperidin-4-one(SALTDATA: FREE)
• CAS NO: 113759-96-9
• Molecular Formula: C₁₁H₁₂ClNO
• Molecular Weight: 209.67
• Mol File: 113759-96-9.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 361 °C at 760 mmHg
• Flash Point: 172.2 °C
• Appearance: /
• Density: 1.232 g/cm³
• Vapor Pressure: 2.13E-05mmHg at 25°C
• Refractive Index: 1.573
• Storage Temp.: 2-8°C
• PKA: 4.41±0.40(Predicted)
• CAS DataBase Reference: 1-(4-CHLORO-PHENYL)-PIPERIDIN-4-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-CHLORO-PHENYL)-PIPERIDIN-4-ONE(113759-96-9)
• EPA Substance Registry System: 1-(4-CHLORO-PHENYL)-PIPERIDIN-4-ONE(113759-96-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 113759-96-9(Hazardous Substances Data)

Usage

General Description

1-(4-CHLORO-PHENYL)-PIPERIDIN-4-ONE is a chemical compound with the formula C11H12ClNO. It is a piperidinone derivative that contains a chloro-phenyl group. 1-(4-CHLORO-PHENYL)-PIPERIDIN-4-ONE is commonly used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. It has also been studied for its potential therapeutic applications, including its reported activity as a selective serotonin reuptake inhibitor. Its chemical structure and properties make it useful for research and development purposes in the pharmaceutical and agricultural industries.

InChI:InChI=1/C11H12ClNO/c12-9-1-3-10(4-2-9)13-7-5-11(14)6-8-13/h1-4H,5-8H2

Upstream product

• 637-87-6 1-Chloro-4-iodobenzene 
• 177-11-7 4,4-ethylenedioxy-piperidine 
• 106-47-8 4-chloro-aniline 
• 3592-25-4 1,5-dichloropentan-3-one 
• 72548-31-3 1,5-Dichloropentan-3-ol 
• 263009-02-5 2'-O-[1-(4-Chlorophenyl)-4-ethoxypiperidin-4-yl]cytidine 
• 263008-94-2 2'-O-[1-(4-Chlorophenyl)-4-ethoxypiperidin-4-yl]uridine 
• 263008-84-0 2'-O-[1-(4-Chlorophenyl)-4-methoxypiperidin-4-yl]uridine 
• 115012-49-2 1-(4-Chlorophenyl)-4,4-dimethoxypiperidine 
• 119836-12-3 4-hydroxy-1-(4-chlorophenyl)piperidine 
• 263009-03-6 2'-O-[1-(4-Chlorophenyl)-4-ethoxypiperidin-4-yl]-2-N-(phenylacetyl)guanosine 
• 263008-98-6 2'-O-[1-(4-Chlorophenyl)-4-ethoxypiperidin-4-yl]-6-N-pivaloyladenosine 
• 263009-01-4 4-N-Benzoyl-2'-O-[1-(4-chlorophenyl)-4-ethoxypiperidin-4-yl]cytidine 
• 263009-04-7 2'-O-[1-(4-Chlorophenyl)-4-ethoxypiperidin-4-yl]guanosine 

Downstream Products

• 113760-03-5 (R)-8-aza-1,4-dioxa-8-(4-chlorophenyl)-2-(2-propenyloxymethyl)spiro[4,5]decane 
• 948022-63-7 C₁₅H₂₀ClNO₃ 
• 1236119-68-8 1-(4-chlorophenyl)-4-methylenepiperidine 
• 1054635-91-4 2'-O-[1-(4-chlorophenyl)-4-ethoxypiperidin-4-yl]-2-N-phenylacetyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxyl)guanosine 
• 908140-97-6 N-(9-{(2R,3R,3aR,9aR)-3-[1-(4-Chloro-phenyl)-4-ethoxy-piperidin-4-yloxy]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl}-9H-purin-6-yl)-2,2-dimethyl-propionamide 
• 908140-96-5 N-(1-{(2R,3R,3aR,9aR)-3-[1-(4-Chloro-phenyl)-4-ethoxy-piperidin-4-yloxy]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl}-2-oxo-1,2-dihydro-pyrimidin-4-yl)-benzamide 
• 263009-03-6 2'-O-[1-(4-Chlorophenyl)-4-ethoxypiperidin-4-yl]-2-N-(phenylacetyl)guanosine 
• 908140-95-4 1-{(2R,3R,3aR,9aR)-3-[1-(4-Chloro-phenyl)-4-ethoxy-piperidin-4-yloxy]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl}-1H-pyrimidine-2,4-dione 
• 263008-98-6 2'-O-[1-(4-Chlorophenyl)-4-ethoxypiperidin-4-yl]-6-N-pivaloyladenosine 
• 263009-01-4 4-N-Benzoyl-2'-O-[1-(4-chlorophenyl)-4-ethoxypiperidin-4-yl]cytidine 
• 263009-04-7 2'-O-[1-(4-Chlorophenyl)-4-ethoxypiperidin-4-yl]guanosine 
• 263009-02-5 2'-O-[1-(4-Chlorophenyl)-4-ethoxypiperidin-4-yl]cytidine 
• 263008-94-2 2'-O-[1-(4-Chlorophenyl)-4-ethoxypiperidin-4-yl]uridine 
• 263008-84-0 2'-O-[1-(4-Chlorophenyl)-4-methoxypiperidin-4-yl]uridine 

Relevant articles and documents

(l)-Proline-catalysed novel tandem reactions of 1-substituted piperidin-4-ones with (E)-4-arylbut-3-en-2-ones: N-substituent mediated product selectivity and synthesis of novel nitrogen heterocycles

(l)-Proline-catalysed reaction of 1-alkyl/aralkylpiperidin-4-ones with (E)-4-arylbut-3-en-2-ones furnishes novel isoquinoline derivatives, with two or three rings, in good yields via tandem Robinson annulation-Michael addition(s) sequences, while the reaction of 1-arylpiperidin-4-ones with (E)-4-arylbut-3-en-2-ones affords 3-azabicyclo[3.3.1]nonan-9-ones via a tandem Michael addition-aldol reaction sequence.

NOVEL TETRAHYDROPYRIDOPYRIMIDINES AND TETRAHYDROPYRIDOPYRIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION

The invention provides novel compounds having the general formula (I): wherein R1, R2, R3, Q, U,W, Z, X and Y are as described herein, compositions including the compounds and methods of using the compounds. These compounds are HbsAg inhibitors and are useful as medicaments for the treatment or prophylaxis of HBV infection.

Some observations relating to the use of 1-aryl-4-alkoxypiperidin-4-yl groups for the protection of the 2′-hydroxy functions in the chemical synthesis of oligoribonucleotides

The comparative rates of acid-catalysed removal often 1-aryl-4-methoxypiperidin-4-yl 8 (R = Me) [including the previously reported Ctmp 5 and Fpmp 6] protecting groups for the 2′-hydroxy functions in oligoribonucleotide synthesis are discussed. These studies have led to the development of the 1-(4-chlorophenyl)-4-ethoxypiperidin-4-yl (Cpep) protecting group 8 (R = Et, R1 = R2 = H, R3 = Cl) which is both more stable than the Ctmp and Fpmp groups at pH 0.5 and more labile at pH 3.75. The influence of the ribonucleoside aglycone on the stability of the 2′-O-Fpmp and 2′-O-Ctmp protecting groups both at low and high pH is examined. The Royal Society of Chemistry 2000.