263149-39-9

Basic information

• Product Name: 7-chloro-6-nitro-4-oxo-1,4-dihydroquinoline-3-carbonitrile
• Synonyms: 7-Chlor-4-hydroxy-6-nitrochinolin-3-carbonitril; 7-Chlor-6-nitro-4-oxo-1,4-dihydrochinolin-3-carbonitril; 7-chloro-4-hydroxy-6-nitroquinoline-3-carbonitrile
• CAS NO: 263149-39-9
• Molecular Formula: C₁₀H₄ClN₃O₃
• Molecular Weight: 249.6101
• Mol File: 263149-39-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 428.677°C at 760 mmHg
• Flash Point: 213.056°C
• Density: 1.65g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.685
• CAS DataBase Reference: 7-chloro-6-nitro-4-oxo-1,4-dihydroquinoline-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 7-chloro-6-nitro-4-oxo-1,4-dihydroquinoline-3-carbonitrile(263149-39-9)
• EPA Substance Registry System: 7-chloro-6-nitro-4-oxo-1,4-dihydroquinoline-3-carbonitrile(263149-39-9)

Safety Data

• Hazardous Substances Data: 263149-39-9(Hazardous Substances Data)

Upstream product

• 5900-58-3 2-amino-4-chloro-benzoic acid methyl ester 
• 89-77-0 2-Amino-4-chlorobenzoic acid 
• 263149-38-8 ethyl 3-[(3-chloro-4-nitrophenyl)amino]-2-cyanoacrylate 
• 108-77-0 1,3,5-trichloro-2,4,6-triazine 
• 348617-32-3 7-chloro-6-nitro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid amide 
• 75001-52-4 7-chloro-6-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester 
• 348617-31-2 7-chloro-6-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 
• 825-41-2 3-chloro-4-nitroaniline 

Downstream Products

• 263149-40-2 4,7-dichloro-6-nitro-3-quinolinecarbonitrile 
• 348617-43-6 6,7-diamino-4-(5-methoxy-2-methylanilino)-3-quinolinecarbonitrile 
• 348617-42-5 7-chloro-4-(5-methoxy-2-methylanilino)-6-nitro-3-quinolinecarbonitrile 
• 348619-33-0 7-azido-4-(5-methoxy-2-methylanilino)-6-nitro-3-quinolinecarbonitrile 
• 348617-45-8 7-chloro-6-nitro-4-(3,4,5-trimethoxyanilino)-3-quinolinecarbonitrile 
• 348619-35-2 6,7-diamino-4-(3,4,5-trimethoxyanilino)-3-quinolinecarbonitrile 
• 348619-34-1 7-azido-6-nitro-4-(3,4,5-trimethoxyanilino)-3-quinolinecarbonitrile 
• 348617-61-8 2-(chloromethyl)-8-(3,4,5-trimethoxyanilino)imidazo[4,5-g]quinoline-7-carbonitrile 

Relevant articles and documents

Method for preparing 7-halo-6-nitro-1,4-dihydroquinoline-4-one-3-carbonitrile

The invention discloses a method for preparing 7-halo-6-nitro-1,4-dihydroquinoline-4-one-3-carbonitrile. The method comprises the following steps of: S1, adopting 2-amino-4-halo benzoic acid as a starting material, and performing esterification on simple fatty alcohol under the action of a catalyst so as to produce 4-halo-2-aminobenzoate; S2, performing a reaction between 4-halo-2-aminobenzoate and 3-dimethylaminoacrylonitrile under the action of an acidic catalyst so as to produce 4-halo-2-((2-cyanovinyl)amino) benzoate; S3, performing cyclization on 4-halo-2-((2-cyanovinyl)amino) benzoate under the action of strong base so as to produce 7-halo-1,4-dihydroquinoline-4-one-3-carbonitrile; and S4, performing nitrification on 7-halo-1,4-dihydroquinoline-4-one-3-carbonitrile in the presence ofa mixture of strong acid and nitric acid to obtain 7-halo-6-nitro-1,4-dihydroquinoline-4-one-3-carbonitrile. According to the method for preparing 7-halo-6-nitro-1,4-dihydroquinoline-4-one-3-carbonitrile, the process route is novel, the novel intermediates are obtained, and the total yield is more than 35%; the method has the advantages of a novel process route, mild reaction conditions and the like.

Substituted 3-cyanoquinolines as protein tyrosine kinases inhibitors

This invention provides compounds of formula 1 wherein R1, G1, G2, R4, Z, X and n are defined herein, or a pharmaceutically acceptable salt thereof, which are useful as antineoplastic agents and in the treatment of polycystic kidney disease.

Tricyclic protein kinase inhibitors

This invention provides compounds of formula 1, having the structure which are useful as inhibitors of protein tyro sine kinase and are antiproliferative agents.