825-41-2

Usage

Uses

Used in Pharmaceutical Industry:
3-Chloro-4-nitroaniline is used as a pharmaceutical and medical intermediate for the synthesis of a range of drugs and medications. Its unique chemical structure allows it to be a key component in the development of new pharmaceuticals, contributing to the advancement of medical treatments.
Used in Organic Synthesis:
In addition to its pharmaceutical applications, 3-chloro-4-nitroaniline is also utilized in organic synthesis for the production of various organic compounds. Its reactivity and functional groups make it a valuable building block for creating a wide array of chemical products, including dyes, agrochemicals, and other specialty chemicals.

InChI:InChI=1/C6H5ClN2O2/c7-5-3-4(8)1-2-6(5)9(10)11/h1-3H,8H2

Upstream product

• 588-07-8 3-Chloroacetanilide 
• 712-33-4 3-chloro-4-nitroacetanilide 
• 108-42-9 3-chloro-aniline 
• 88-73-3 2-Chloronitrobenzene 
• 118535-52-7 N,N-tetramethylene-thiocarbamoyl-sulphenamide 
• 7664-93-9 sulfuric acid 
• 7697-37-2 nitric acid 
• 13208-31-6 N_.N'-Di-(m-chlor-phenyl)-harnstoff 
• 64-19-7 acetic acid 
• 865-47-4 potassium tert-butylate 
• 619-16-9 1-chloro-2,5-dinitrobenzene 

Downstream Products

• 34662-29-8 1-chloro-5-cyano-2-nitrobenzene 
• 62406-69-3 2,3,6-trichloro-4-nitro-aniline 
• 89284-60-6 2-chloro-4-iodo-1-nitro-benzene 
• 72115-08-3 5-amino-2-nitrobenzonitrile 
• 857007-35-3 (3-chloro-4-nitro-phenyl)-phosphonic acid 
• 88-73-3 2-Chloronitrobenzene 
• 5925-26-8 benzoic acid-(3-chloro-4-nitro-anilide) 
• 712-33-4 3-chloro-4-nitroacetanilide 
• 58416-32-3 5-chloro-6-nitroquinoline 
• 58416-31-2 7-chloro-6-nitroquinoline 
• 17815-98-4 3-chloro-4-nitro-N,N-dimethylaniline 
• 5540-57-8 Cyclopentanecarboxylic acid (3-chloro-4-nitro-phenyl)-amide 
• 5540-56-7 Undec-10-enoic acid (3-chloro-4-nitro-phenyl)-amide 
• 66608-61-5 4-Nitro-3-(n-propylthio)aniline 

Relevant academic research and scientific papers

Fabrication of magnetically separable ruthenium nanoparticles decorated on channelled silica microspheres: Efficient catalysts for chemoselective hydrogenation of nitroarenes

Fe3O4-SiO2microspheres were synthesized by a three-step synthetic procedure involving silica coating, surface capping, and surface modification. These magnetic mesoporous microspheres were employed as sorbents for the incorporation of ultrasmall Ru nanoparticles (2-5 nm) followed by thermal aggregation of the microspheres for achieving better heterogeneity and low leaching. The Ru decorated Fe3O4-SiO2microspheres (Ru@Fe3O4-CSM) were applied as chemoselective catalysts to convert more than 20 substituted nitroarenes to corresponding amines with good-to-excellent conversion (77-99%) and selectivity (70-100%) under mild conditions; the catalyst can be magnetically recovered within a frame of 90s (recovery time-lapse) and reused up to 5 times without significant decrease in activity or selectivity. Magnetic hysteresis studies were performed to elucidate the magnetic behavior of the ruthenium decorated materials.

PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS

Compounds of the formula I or II: wherein X, m, Ar, R1 and R2 are as defined herein. The subject compounds are useful for treatment of IRAK-mediated conditions.

Guanidinium nitrate: A novel reagent for aryl nitrations

Nitration of various aromatic compounds utilising guanidinium nitrate in 85% sulfuric acid as a nitrating agent has been studied.

Nitroarylamines via the Vicarious Nucleophilic Substitution of Hydrogen: Amination, Alkylamination, and Arylamination of Nitroarenes with Sulfenamides

A new reaction of sulfenamides with electrophilic arenes under basic conditions is described. The σ adducts formed from nitroarenes and the anions of sulfenamides undergo elimination of thiol to produce the corresponding o- and/or p-nitroanilines. This reaction is analogous to the known alkylation and hydroxylation of nitroarenes via the vicarious nucleophilic substitution of hydrogen (VNS). The reaction gives access to a wide range of substituted nitroanilines, nitronaphthylamines, and aminoheterocycles. By means of the reaction with N-alkyl- and N-arylsulfenamides, it is possible to obtain N-alkylnitroanilines and nitrodiarylamines. By varying the structure of sulfenamide and the reaction conditions, particularly the nature and concentration of the base, it is possible to control the orientation of animation.

Process for the preparation of aromatic amines

Electrophilic aromatic compounds can be reacted with sulphenamides in the presence of bases to form the corresponding aromatic amines.

Anthelmintically active benzenepropanamide derivatives

This invention is directed to a method for treating helminthiasis in an animal which method comprises administering to an animal in need thereof an anthelmintically effective amount of a compound of the Formula (I): STR1 wherein Z is oxygen or sulfur;R 1 is hydrogen or lower alkyl; andR 2, R 3, R 4 and R 5 are independently hydrogen, halo, lower haloalkyl, lower alkoxy, lower haloalkoxy, nitro, cyano, halophenoxy, haloalkylphenoxy, thiocyano or isothiocyano, provided that R 2 and R 3 cannot simultaneously be hydrogen and that R 4 and R 5 cannot simultaneously be hydrogen; or a pharmaceutically acceptable salt thereof, and pharmaceutical compositions formulated therewith. This invention is also directed to novel anthelmintically active benzenepropanamides of Formula (I) wherein Z is oxygen.