825-41-2

Basic information

• Product Name: 3-CHLORO-4-NITROANILINE
• Synonyms: 3-CHLORO-4-NITROANILINE;4-Amino-2-chloronitrobenzene;3-Chloro-4-nitroaniline,97%;(3-chloro-4-nitro-phenyl)amine;2-Chloro-4-aminonitrobenzene
• CAS NO: 825-41-2
• Molecular Formula: C₆H₅ClN₂O₂
• Molecular Weight: 172.57
• EINECS: 1592732-453-0
• Product Categories: Anilines, Aromatic Amines and Nitro Compounds
• Mol File: 825-41-2.mol
• Article Data: 7

Chemical Properties

• Melting Point: 158°C
• Boiling Point: 366.8 °C at 760 mmHg
• Flash Point: 175.7 °C
• Appearance: /
• Density: 1.494
• Vapor Pressure: 1.42E-05mmHg at 25°C
• Refractive Index: 1.646
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: -0.06±0.10(Predicted)
• Water Solubility: Insoluble in water.
• CAS DataBase Reference: 3-CHLORO-4-NITROANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-4-NITROANILINE(825-41-2)
• EPA Substance Registry System: 3-CHLORO-4-NITROANILINE(825-41-2)

Safety Data

• Hazard Codes: Xi
• RIDADR: UN 2237 6.1/PG III
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 825-41-2(Hazardous Substances Data)

Usage

Chemical Properties

light yellow powder

Uses

3-Chloro-4-nitroaniline is used as a pharmaceutical and medical intermediate.

InChI:InChI=1/C6H5ClN2O2/c7-5-3-4(8)1-2-6(5)9(10)11/h1-3H,8H2

Upstream product

• 108-42-9 3-chloro-aniline 
• 7664-93-9 sulfuric acid 
• 7697-37-2 nitric acid 
• 13208-31-6 N_.N'-Di-(m-chlor-phenyl)-harnstoff 
• 64-19-7 acetic acid 
• 619-16-9 1-chloro-2,5-dinitrobenzene 
• 865-47-4 potassium tert-butylate 
• 88-73-3 2-Chloronitrobenzene 
• 118535-52-7 N,N-tetramethylene-thiocarbamoyl-sulphenamide 
• 712-33-4 3-chloro-4-nitroacetanilide 
• 588-07-8 3-Chloroacetanilide 

Downstream Products

• 5925-26-8 benzoic acid-(3-chloro-4-nitro-anilide) 
• 712-33-4 3-chloro-4-nitroacetanilide 
• 5540-57-8 Cyclopentanecarboxylic acid (3-chloro-4-nitro-phenyl)-amide 
• 5540-91-0 Nonanoic acid (3-chloro-4-nitro-phenyl)-amide 
• 5540-56-7 Undec-10-enoic acid (3-chloro-4-nitro-phenyl)-amide 
• 5540-88-5 4-Methyl-pentanoic acid (3-chloro-4-nitro-phenyl)-amide 
• 5540-93-2 2,2-Dimethyl-octanoic acid (3-chloro-4-nitro-phenyl)-amide 
• 5540-94-3 Undecanoic acid (3-chloro-4-nitro-phenyl)-amide 
• 5540-55-6 2-Bromo-nonanoic acid (3-chloro-4-nitro-phenyl)-amide 
• 5540-87-4 Hexanoic acid (3-chloro-4-nitro-phenyl)-amide 
• 5925-44-0 Tetradecanoic acid (3-chloro-4-nitro-phenyl)-amide 
• 5683-81-8 N-(3-Chloro-4-nitro-phenyl)-3-methyl-butyramide 
• 5596-26-9 Cyclobutanecarboxylic acid (3-chloro-4-nitro-phenyl)-amide 
• 87200-54-2 2-chloro-4-isothiocyanato-1-nitrobenzene 

Relevant articles and documents

Fabrication of magnetically separable ruthenium nanoparticles decorated on channelled silica microspheres: Efficient catalysts for chemoselective hydrogenation of nitroarenes

Fe3O4-SiO2microspheres were synthesized by a three-step synthetic procedure involving silica coating, surface capping, and surface modification. These magnetic mesoporous microspheres were employed as sorbents for the incorporation of ultrasmall Ru nanoparticles (2-5 nm) followed by thermal aggregation of the microspheres for achieving better heterogeneity and low leaching. The Ru decorated Fe3O4-SiO2microspheres (Ru@Fe3O4-CSM) were applied as chemoselective catalysts to convert more than 20 substituted nitroarenes to corresponding amines with good-to-excellent conversion (77-99%) and selectivity (70-100%) under mild conditions; the catalyst can be magnetically recovered within a frame of 90s (recovery time-lapse) and reused up to 5 times without significant decrease in activity or selectivity. Magnetic hysteresis studies were performed to elucidate the magnetic behavior of the ruthenium decorated materials.

Guanidinium nitrate: A novel reagent for aryl nitrations

Nitration of various aromatic compounds utilising guanidinium nitrate in 85% sulfuric acid as a nitrating agent has been studied.

Process for the preparation of aromatic amines

Electrophilic aromatic compounds can be reacted with sulphenamides in the presence of bases to form the corresponding aromatic amines.