26321-38-0

Basic information

• Product Name: 2-(4-fluorophenyl)-3,3-dimethyl-3H-indole
• Synonyms: 2-(4-fluorophenyl)-3,3-dimethyl-3H-indole
• CAS NO: 26321-38-0
• Molecular Weight: 239.292
• Mol File: 26321-38-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(4-fluorophenyl)-3,3-dimethyl-3H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-fluorophenyl)-3,3-dimethyl-3H-indole(26321-38-0)
• EPA Substance Registry System: 2-(4-fluorophenyl)-3,3-dimethyl-3H-indole(26321-38-0)

Safety Data

• Hazardous Substances Data: 26321-38-0(Hazardous Substances Data)

Upstream product

• 13524-75-9 2-(2-methoxyphenyl)-2-methylpropanenitrile 
• 1493-23-8 (4-fluorophenyl)lithium 
• 321-28-8 1-fluoro-2-methoxybenzene 

Relevant articles and documents

Preparation of Indolenines via Nucleophilic Aromatic Substitution

An unusual aromatic substitution to access indolenines is described. 2-(2-Methoxyphenyl)acetonitrile derivatives are reacted with various alkyl and aryl Li reagents to furnish the corresponding indolenine products, constituents of natural products, and cyanine dyes such as indocyanine green. This new method was used to synthesize 41 indolenines with large functional group tolerance, and selected examples were further converted to the corresponding indolenine dyes. Key experiments provide insight into the mechanism of this nucleophilic aromatic substitution.