13524-75-9

Upstream product

• 7035-03-2 2-methoxy-benzeneacetonitrile 
• 74-88-4 methyl iodide 
• 78-82-0 Isobutyronitrile 
• 321-28-8 1-fluoro-2-methoxybenzene 

Downstream Products

• 6636-32-4 3,3-dimethyl-2-phenyl-3H-indole 
• 26321-38-0 2-(4-fluorophenyl)-3,3-dimethyl-3H-indole 
• 1640-39-7 2,3,3-trimethylindoleniune 
• 1454914-77-2 3,3-dimethyl-2-(4-(trifluoromethyl)phenyl)-3H-indole 
• 26321-40-4 2-(4-methoxyphenyl)-3,3-dimethyl-3H-indole 
• 1620581-24-9 2-(5-(indolin-1-ylsulfonyl)-2-methoxyphenyl)-2-methylpropanenitrile 
• 858007-31-5 2-(2-methoxyphenyl)-2-methylpropanal 

Relevant academic research and scientific papers

Cobalt-catalyzed C[sbnd]H activation/C[sbnd]O formation: Synthesis of benzofuranones

Herein, C[sbnd]H activation/C[sbnd]O formation reaction using novel cobalt catalytic system is reported. This reaction was given benzofuranones in moderate to excellent yields at room-temperature under air reaction conditions. The introduced strategy is efficient and low-cost method to synthesized benzofuranones from α,α-disubstitution acetic acid.

Preparation of Indolenines via Nucleophilic Aromatic Substitution

An unusual aromatic substitution to access indolenines is described. 2-(2-Methoxyphenyl)acetonitrile derivatives are reacted with various alkyl and aryl Li reagents to furnish the corresponding indolenine products, constituents of natural products, and cyanine dyes such as indocyanine green. This new method was used to synthesize 41 indolenines with large functional group tolerance, and selected examples were further converted to the corresponding indolenine dyes. Key experiments provide insight into the mechanism of this nucleophilic aromatic substitution.

Heck-type 5-endo-trig cyclizations promoted by vinylic fluorines: Ring-fluorinated indene and 3H-pyrrole syntheses from 1,1-difluoro-1-alkenes

Arylpalladium or aminopalladium species bearing a 2,2-difluorovinyl group undergo an unusual 5-endo alkene insertion followed by β-fluorine elimination. These processes provide a facile access to ring-fluorinated five-membered carbocyclic and heterocyclic

Process for preparing benzylnitriles

A process is described for preparing an aromatic compound substituted by a tertiary nitrile of Formula (1.0.0): comprising treating a substituted aromatic compound of Formula (2.0.0): with a secondary nitrile of Formula (3.0.0): in the presence of a base having a pKanumerical value in the range of from about 17 to about 30, provided that the difference in pKanumerical values between said base and the corresponding tertiary nitrile of Formula (3.0.0) is no more than about 6; in an aprotic solvent having a dielectric constant (∈) of less than about 20; and at a reaction temperature in the range of from about 0° C. to about 120° C.; whereby there is formed said tertiary-nitrile-substituted aromatic compound final product of Formula (1.0.0); wherein the constituent parts W1, W2, W3, W4, and W5; and the substituent moieties R1, R2, R3, R4, R5, R6, and R7in the compounds of Formulas (1.0.0), (2.0.0) and (3.0.0) are selected from known organic groups and radicals as further detailed in the instant specification.

5-Cyano-2,3-dihydrobenzofurans useful as herbicides

The invention provides herbicidally-active 2,3-dihydro-5-cyanobenzofurans of the formula: STR1 (wherein: R1 and R2 together represent =O or R1 represents hydrogen and R2 represents hydrogen, hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, alkylthiocarbonyloxy, halogen, isothiocyanato, amino, alkylamino, dialkylamino, arylamino, acylamino, alkoxycarbonylamino, alkylthiocarbonylamino, N-bonded heterocyclyl, cyano or alkylthio; R3 and R4 together represent alkylene or each represent hydrogen or alkyl; and R5, R6 and R7, which may be the same or different, each represent hydrogen, halogen, alkyl, alkoxy, acyl or cyano), processes for their preparation and herbicidal compositions containing them.