263270-02-6

Basic information

• Product Name: 5-BROMO-3-PYRIDINECARBOXYLIC ACID TERT-BUTYL ESTER
• Synonyms: 5-BROMO-3-PYRIDINECARBOXYLIC ACID TERT-BUTYL ESTER;TERT-BUTYL 5-BROMONICOTINATE;T-BUTYL 5-BROMO-3-PYRIDINECARBOXYLATE;T-BUTYL 5-BROMONICOTINATE;tert-Butyl 5-bromonicotinate 98%;5-Bromo-nicotinic acid tert-butyl ester;tert-butyl 5-bromopyridine-3-carboxylate;tert-Butyl5-bromonicotinate98%
• CAS NO: 263270-02-6
• Molecular Formula: C₁₀H₁₂BrNO₂
• Molecular Weight: 258.11
• Product Categories: blocks;Pyridines
• Mol File: 263270-02-6.mol
• Article Data: 10

Chemical Properties

• Melting Point: 53-55
• Boiling Point: 279.8 °C at 760 mmHg
• Flash Point: 123 °C
• Appearance: /
• Density: 1.385 g/cm³
• Vapor Pressure: 0.00392mmHg at 25°C
• Refractive Index: 1.531
• Storage Temp.: Keep Cold
• PKA: 0.86±0.20(Predicted)
• CAS DataBase Reference: 5-BROMO-3-PYRIDINECARBOXYLIC ACID TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-3-PYRIDINECARBOXYLIC ACID TERT-BUTYL ESTER(263270-02-6)
• EPA Substance Registry System: 5-BROMO-3-PYRIDINECARBOXYLIC ACID TERT-BUTYL ESTER(263270-02-6)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 263270-02-6(Hazardous Substances Data)

Usage

General Description

5-BROMO-3-PYRIDINECARBOXYLIC ACID TERT-BUTYL ESTER is a chemical compound that belongs to the class of pyridine derivatives. It is an ester, which means it is derived from the condensation of an acid and an alcohol. 5-BROMO-3-PYRIDINECARBOXYLIC ACID TERT-BUTYL ESTER is commonly used in the synthesis of pharmaceuticals and agrochemicals. It is also utilized as a building block in organic chemistry and is known for its versatile reactivity. The tert-butyl ester moiety in the compound provides stability and can protect the carboxylic acid group from unwanted reactions, making it an important intermediate in various chemical processes.

InChI:InChI=1/C10H12BrNO2/c1-10(2,3)14-9(13)7-4-8(11)6-12-5-7/h4-6H,1-3H3

Upstream product

• 20826-04-4 5-bromo-3-pyridinecarboxylic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 67098-46-8 O-tert-butyl-N,N-diisopropyl-isourea 
• 75-65-0 tert-butyl alcohol 

Downstream Products

• 887579-69-3 tert-butyl 5-cyanonicotinate 
• 1309982-38-4 C₁₆H₂₄BNO₄ 

Relevant articles and documents

Compounds and methods of use

Compounds are provided according to Formula (I): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein X1, X2, X3, X4, Y, A, L1, L2, R1, R2, R5, m and n are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.

NOVEL FERROPORTIN INHIBITORS

The invention relates to novel ferroportin inhibitors of the general formula (I) pharmaceutical compositions comprising them and the use thereof as medicaments, in particular for the prophylaxis and/or treatment of diseases caused by a lack of hepcidin or iron metabolism disorders, such as particularly iron overload states such as in particular thalassemia and hemochromatosis.

Preparation of 2-, 4-, 5-, and 6-aminonicotinic acid tert-butyl esters

Procedures are reported to prepare the tert-butyl esters of 2-aminonicotinic acid, 4-aminonicotinic acid, 5-aminonicotinic acid, and 6-aminonicotinic acid from 2-chloronicotinic acid, 4-chloronicotinic acid, 5-bromonicotinic acid, and 6-chloronicotinic acid, respectively, without need for purification of intermediates. Copyright