263274-26-6

Basic information

• Product Name: 6-Heptenoic acid, 7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3-hydroxy-5-oxo-, methyl ester, (6E)-
• CAS NO: 263274-26-6
• Molecular Formula: C25H26FNO4
• Molecular Weight: 423.484
• Mol File: 263274-26-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 6-Heptenoic acid, 7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3-hydroxy-5-oxo-, methyl ester, (6E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Heptenoic acid, 7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3-hydroxy-5-oxo-, methyl ester, (6E)-(263274-26-6)
• EPA Substance Registry System: 6-Heptenoic acid, 7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3-hydroxy-5-oxo-, methyl ester, (6E)-(263274-26-6)

Safety Data

• Hazardous Substances Data: 263274-26-6(Hazardous Substances Data)

Upstream product

• 877305-53-8 (E)-7-[3-(4-fluorophenyl)-1-isopropyl-2-indolyl]-3-tert-butyldimethylsilanyloxy-5-oxo-6-heptenoic acid methyl ester 
• 202479-37-6 methyl-erythro-(E)-3,5-dihydroxy-7-[3'-(4-fluorophenyl)-1'-(1-methylethyl)indol-2'-yl]hept-6-enoate 

Downstream Products

• 786710-21-2 methyl [3R,5S-(E)]-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoate 

Relevant articles and documents

Mechanism of antioxidative activity of fluvastatin-determination of the active position

In order to clarify the mechanism of action for the antioxidative activity of fluvastatin sodium (FLV, (±)-sodium (3RS, 5RS, 6E)-7-[3-(4- fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptanoate) and its derivatives, reaction of the corresponding methyl ester of FLV with di-tert-butyl diperoxyoxalate was examined, and the corresponding keto derivative was isolated from the reaction mixture. On the basis of this result, it was concluded that the active site is the allylic carbon conjugated with the indole ring.