263327-99-7

Upstream product

• 3462-97-3 (4-methoxybenzyl)triphenylphosphonium bromide 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 824-94-2 p-methoxybenzyl chloride 
• 696-62-8 para-iodoanisole 
• 14737-89-4 3,4-dimethoxy-trans-cinnamic acid 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 6380-23-0 3,4-dimethoxystyrene 
• 100-66-3 methoxybenzene 
• 1145-93-3 diethyl 4-methoxybenzylphosphonate 
• 104-01-8 4-Methoxyphenylacetic acid 
• 87751-79-9 (Z)-3,4-dimethoxy-α-(4-methoxyphenyl)cinnamic acid 

Downstream Products

• 2898-54-6 3,4,4'-trimethoxybenzophenone 
• 56261-33-7 2,3,6-trimethoxyphenanthrene 
• 18513-95-6 (E)-3,4,4'-trimethoxystilbene 
• 145356-39-4 3',4',4-trihydroxystilbene 

Relevant academic research and scientific papers

3,4,4′-Trihydroxy-trans-stilbene, an analogue of resveratrol, is a potent antioxidant and cytotoxic agent

Resveratrol (3,5,4′-trihydroxy-trans-stilbene) is a naturally occurring polyphenol widely distributed in food and dietary plants. This phytochemical has been intensively studied as an efficient antioxidant and anticancer agent, and a variety of substituted stilbenes have been developed in order to improve the potency of resveratrol. In this work, we described the synthesis of 3,4,4-trihydroxy-trans-stilbene (3,4,4′-THS), an analogue of resveratrol, and studied its antioxidant and cytotoxic activity in vitro. 3,4,4-THS was much more efficient than resveratrol in protecting against free radical-induced lipid peroxidation, photo-sensitized DNA oxidative damage, and free radical-induced hemolysis of human red blood cells. More potent growth inhibition in cultured human leukemia cells (HL-60) was also observed for 3,4,4-THS. The relationship between the antioxidant efficiency and cytotoxic activity was discussed, with the emphasis on inhibition of the free radical enzyme ribonucleotide reductase by antioxidants. The result that this subtle structure modification of resveratrol drastically improves its bioactivity provides important strategy to develop novel resveratrol-based molecules.

Stilbene synthesis through decarboxylative cross-coupling of substituted cinnamic acids with aryl halides

The Pd-catalyzed decarboxylative cross-coupling reaction between cinnamic acid and aryl iodide derivatives was studied using both homogeneous and heterogeneous Pd-catalysts. It was demonstrated that simple Pd(OAc)2 can catalyze this reaction wi

Carbene based palladium-catalyzed Mizoroki-Heck reaction

Different perhydrobenzimidazolinium chloride salts were used as a ligand for PdcatalysedMizoroki-Heck reaction. The in situ generation of carbene is the attractive feature of this catalytic system. The corresponding Mizoroki-Heck products were obtained in good yield.

A MICROWAVE INDUCED ONE POT PROCESS FOR THE PREPARATION OF ARYLETHENES

The invention entitled "A Microwave Induced One Pot Process for The Preparation of Arylethenes" provides a method for the preparation of commercially important 2- or 4-hydroxy substituted arylethenes like styrenes or stilbenes in one pot utilizing cheaper substrates in the form of 2- or 4-hydroxy substituted cinnamic acids and their derivatives as well as reagents in the form of base such as sodium hydroxide, potassium hydroxide, lithium hydroxide, sodium bicarbonate, sodium carbonate, potassium bicarbonate, potassium carbonate, ammonium acetate, imidazole, methylimidazole and the combination thereof, with or without solvent such as dimethylformamide, dimethylsulfoxide, ethylene glycol, diethylene glycol, acetonitrile, acetone, methyl imidazoles, ionic liquid, water and the like. The reaction time vary from 1 min-12 hrs and yield of the products from 49-76% depending upon the base, acid, substrate source of heating monomode or multimode microwave or conventional. It is important to mention that the presence of 2- or 4-hydroxy substitution at phenyl ring of cinnamic acids and their derivatives is essential requirements towards formation of corresponding arylethenes in one step.

C8c-C15 monoseco-analogues of the phenanthroquinolizidine alkaloids julandine and cryptopleurine exhibiting potent anti-angiogenic properties

Four enantiomerically pure monoseco-analogues, 5, 7, 9, and 11, of the phenanthroquinolizidine alkaloid julandine (1) and four of congener cryptopleurine (2), viz. compounds 6, 8, 10, and 12, have been prepared and subjected to preliminary biological eval

Direct injection gas chromatographic mass spectrometric assay for trans-resveratrol

We have developed a novel method to measure the concentration of the trihydroxystilbene trans-resveratrol suitable for the analysis of wine and other biological materials. Solid-phase extraction is carried out on a reversed-phase disposable C-18 cartridge