2898-54-6

Upstream product

• 91-16-7 1,2-dimethoxybenzene 
• 100-07-2 4-methoxy-benzoyl chloride 
• 100-66-3 methoxybenzene 
• 3535-37-3 3,4-dimethoxybenzoic acid chloride 
• 263327-99-7 4,3’,4’-trimethoxystilbene 
• 1178964-09-4 2-(3,4-dimethoxyphenyl)-2-(4-methoxyphenyl)-1,3-dithiane 
• 2898-55-7 (3,4-dimethoxy-phenyl)-(4-methoxy-phenyl)-methane 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 2859-78-1 4-Bromoveratrole 
• 98-86-2 acetophenone 
• 100-09-4 4-methoxybenzoic acid 
• 1426391-14-1 bis[(p-anisyl)(3,4-dimethoxyphenyl)methyl] ether 
• 944682-89-7 (3,4-dimethoxyphenyl)(4-methoxyphenyl)methanol 
• 84462-03-3 4-ethoxycarbonyloxy-3-methoxy-benzoic acid 

Downstream Products

• 2898-55-7 (3,4-dimethoxy-phenyl)-(4-methoxy-phenyl)-methane 
• 2898-52-4 4,5,4'-trimethoxy-2-nitro-benzophenone 
• 4254-44-8 3,4,4'-trimethoxy-thiobenzophenone 
• 100-09-4 4-methoxybenzoic acid 
• 93-07-2 Veratric acid 
• 101287-65-4 (3,4-dimethoxyphenyl)(4-methoxyphenyl)methylamine 
• 1496524-42-5 isopropyl((2S)-1-(((3,4-dimethoxylphenyl)(4-methoxylphenyl)methyl)amino)-3-methyl-1-oxobutan-2-yl)carbamate 
• 860594-06-5 (3,4-dimethoxyphenyl)(4-methoxyphenyl)methanone oxime 
• 101719-18-0 acetic acid-[4,5-dimethoxy-2-(4-methoxy-benzyl)-anilide] 
• 2898-48-8 2-amino-4,5,4'-trimethoxy-benzophenone 
• 2898-49-9 5,6-dimethoxy-3-(4-methoxy-phenyl)-benzo[c]isoxazole 
• 93652-35-8 1-(3,4-dimethoxy-phenyl)-1-(4-methoxy-phenyl)-ethene 
• 1239703-11-7 2,3'-dibromo-4,4',5-trimethoxydiphenylmethanone 

Relevant academic research and scientific papers

Selective Oxidation of Alkylarenes to the Aromatic Ketones or Benzaldehydes with Water

Here a palladium-catalyzed oxidation method for converting alkylarenes into the aromatic ketones or benzaldehydes with water as the only oxygen donor is reported. This C-H bond oxidation functionalization does not require other oxidants and hydrogen accep

Arene Cyanation via Cation-Radical Accelerated-Nucleophilic Aromatic Substitution

Herein we describe a cation radical-accelerated-nucleophilic aromatic substitution (CRA-SNAr) of alkoxy arenes utilizing a highly oxidizing acridinium photoredox catalyst and acetone cyanohydrin, an inexpensive and commercially available cyanide source. This cyanation is selective for carbon-oxygen (C-O) bond functionalization and is applicable to a range of methoxyarenes and dimethoxyarenes. Furthermore, computational studies provide a model for predicting regioselectivity and chemoselectivity in competitive C-H and C-O cyanation of methoxyarene cation radicals.

One-pot synthesis of diarylmethanones through palladium-catalyzed sequential coupling and aerobic oxidation of aryl bromides with acetophenone as a latent carbonyl donor

A one-pot palladium-catalyzed synthesis of symmetrical and unsymmetrical diarylmethanones using acetophenone and aryl bromides as raw materials has been developed. In this reaction, acetophenone acts as a latent carbonyl donor and two pathways of palladium-catalyzed sequential coupling and aerobic oxidation are identified. The reaction is applicable to a spectrum of substrates and delivers the products in moderate to good yields. This method can be used for the synthesis of ketoprofen, a nonsteroidal anti-inflammatory drug, in a two-step procedure and 45% overall yield.

Design, synthesis, and fungicidal activity of novel carboxylic acid amides represented by N-benzhydryl valinamode carbamates

Carboxylic acid amide (CAA) fungicides are an important class of agricultural fungicide with oomycete activity and low toxicity toward mammalian cells. To find CAA analogues with high activity against resistant pathogens, a series of substituted N-benzhydryl valinamide carbamate derivatives were designed and synthesized by introducing substituted aromatic rings into valinamide carbamate leads. Bioassays showed that some title compounds exhibited very good in vitro fungicidal activity against Phytophthora capsici and in vivo fungicidal activities against Pseudoperonospora cubensis. Topomer CoMFA was performed to explore the structure-activity relationship on the basis of the in vitro data. The dimethoxy substituted aromatic analogue 9e was found to display higher in vitro fungicidal activity against Phytophthora capsici than iprovalicarb but lower activity than mandipropamid, and higher in vivo fungicidal activity against Pseudoperonospora cubensis than dimethomorph at a dosage of 6.25 μg mL-1. This journal is the Partner Organisations 2014.

Iodine-catalyzed disproportionation of aryl-substituted ethers under solvent-free reaction conditions

Iodine was demonstrated to be an efficient catalyst for disproportionation of aryl-substituted ethers under solvent-free reaction conditions. Variously substituted 1,1,1′,1′-tetraaryldimethyl ethers were transformed into the corresponding diarylketone and diarylmethane derivatives. I 2-catalyzed transformation of 4-methoxyphenyl substituted ethers yielded mono- and dialkylated Friedel-Crafts products as well. Treatment of trityl alkyl and trityl benzyl ethers with a catalytic amount of iodine produced triphenylmethane and the corresponding aldehydes and ketones. The electron-donating substituents facilitated the reaction, while the electron-withdrawing groups retarded it; the difference in reactivity is not very high. Such an observation may be in favour of hydride transfer, predominantly from the less electron rich side of the ether with more stable carbocation formation. With the isotopic studies it was established that a substantial portion of the C-H bond scission took place in the rate-determining step, while the carbonyl oxygen atom originated from the starting ether, and not from the air. The transformation took place under air and under argon, and HI was not a functioning catalyst.

Synthesis and deprotection of 1,3-Dithianes and 1,3-Dithiolanes by polyphosphoric acid

A simply, mild and efficient method for the deprotection of 1,3-dithianes and 1,3-dithiolanes to their corresponding carbonyl compounds using a mixture of polyphosphoric acid and acetic acid at 20-45 °C is reported.

Synthesis and biological activity of halophenols as potent antioxidant and cytoprotective agents

A series of new bromophenols and chlorophenols were prepared by a practical route. The in vitro antioxidative activity of the halophenols was evaluated by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging assay, and their cytoprotective activity was also tested on hydrogen peroxide (H2O2)-induced injury in human umbilical vein endothelial cells (HUVEC). All halophenols tested displayed moderate to good DPPH radical-scavenging activity, and two bromophenols, 2,3′-dibromo-4,5,6′-trihydroxydiphenylmethanone (16c) and 2,3-dibromo-4,5-dihydroxydiphenylmethanone (17c) exhibited high protective activity against H2O2-induced injury in HUVEC with EC50 values of 0.4 and 0.8 μM, respectively. The preliminary structure-activity relationships of these compounds were also investigated in order to determine the essential structures required for their bioactivities.

One-pot two-step oxidative cleavage of 1,2-arylalkenes to aryl ketones instead of arylaldehydes in an aqueous medium: A complementary approach to ozonolysis

A new approach has been developed for a one-pot and selective oxidative cleavage of aryl- and 1,2-diarylalkenes leading to one-carbon shorter aryl ketones; thereby, providing a complementary approach to classical ozonolysis. The methodology was applicable to diverse aromatic and polyaromaticarylalkenes bearing electron-donating or -withdrawing groups on the aromatic ring. The protocol also provided a useful one-pot oxidative cleavage-condensation sequence, which could potentially have important applications in natural product total synthesis. A one-pot, two-step approach has been achieved for the oxidative cleavage of 1,2-disubstituted arylalkenes into the corresponding aryl ketones instead of arylaldehydes (see scheme; NIS = N-iodosuccinimide; CTAB = cetyltrimethylammonium bromide; PDC/TBHP = pyridinium dichromate/tert-butyl hydroperoxide). The methodology also led to a valuable one-pot oxidative cleavage-condensation reaction that has widespread utility in the total synthesis of natural products.

Diphenylethylene compounds and uses thereof

The present invention relates to Diphenylethylene Compounds and compositions comprising a Diphenylethylene Compound. The present invention also relates to methods for preventing or treating various diseases and disorders by administering to a subject in need thereof one or more Diphenylethylene Compounds. In particular, the invention relates to methods for preventing or treating cancer or an inflammatory disorder by administering to a subject in need thereof one or more Diphenylethylene Compounds. The present invention further relates to articles of manufacture and kits comprising one or more Diphenylethylene Compounds.

Photochromic naphthopyrans, compositions and articles containing them

PCT No. PCT/US97/13723 Sec. 371 Date Oct. 23, 1998 Sec. 102(e) Date Oct. 23, 1998 PCT Filed Jul. 16, 1997 PCT Pub. No. WO98/04937 PCT Pub. Date Feb. 5, 1998The invention relates to photochromic compounds of general formula (I), in which: R3 and R5 are C1-C6 alkoxy groups and the rest of the R groups represent various substituents.