263389-53-3Relevant academic research and scientific papers
The base-free van Leusen reaction of cyclic imines on water: Synthesis of N-fused imidazo 6,11-dihydro β-carboline derivatives
Satyam, Killari,Murugesh,Suresh, Surisetti
, p. 5234 - 5238 (2019/06/07)
Construction of imidazoles has been demonstrated on water under base-free conditions. The reaction of dihydro β-carboline imines and p-toluenesulfonylmethyl isocyanides furnished the corresponding substituted N-fused imidazo 6,11-dihydro β-carboline derivatives in very good yields under ambient conditions. The use of deuterium oxide (D2O) as a solvent enabled the incorporation of deuterium isotopes in the imidazole ring.
In silico-driven multicomponent synthesis of 4,5- and 1,5-disubstituted imidazoles as indoleamine 2,3-dioxygenase inhibitors
Fallarini,Massarotti,Gesù,Giovarruscio,Coda Zabetta,Bergo,Giannelli,Brunco,Lombardi,Sorba,Pirali
supporting information, p. 409 - 419 (2016/04/01)
Indoleamine 2,3-dioxygenase is involved in pathological immune escape and has recently become an attractive target for anti-cancer therapy. 4-Phenylimidazole (4-PI) provides a promising starting point for the development of IDO1 inhibitors. With the aim o
Design and modular parallel synthesis of a MCR derived α-helix mimetic protein-protein interaction inhibitor scaffold
Antuch, Walfrido,Menon, Sanjay,Chen, Quin-Zene,Lu, Yingchun,Sakamuri, Sukumar,Beck, Barbara,Schauer-Vukasinovic, Vesna,Agarwal, Seema,Hess, Sibylle,Doemling, Alexander
, p. 1740 - 1743 (2007/10/03)
A terphenyl α-helix mimetic scaffold recognized to be capable of disrupting protein-protein interactions was structurally morphed into an easily amenable and versatile multicomponent reaction (MCR) backbone. The design, modular in-parallel library synthes
