263389-54-4Relevant academic research and scientific papers
A Structure-based Design Approach for Generating High Affinity BRD4 D1-Selective Chemical Probes
Cui, Huarui,Divakaran, Anand,Hoell, Zachariah J.,Ellingson, Mikael O.,Scholtz, Cole R.,Zahid, Huda,Johnson, Jorden A.,Griffith, Elizabeth C.,Gee, Clifford T.,Lee, Amani L.,Khanal, Shalil,Shi, Ke,Aihara, Hideki,Shah, Vijay H.,Lee, Richard E.,Harki, Daniel A.,Pomerantz, William C. K.
, p. 2342 - 2360 (2022/01/27)
Chemical probes for epigenetic proteins are essential tools for dissecting the molecular mechanisms for gene regulation and therapeutic development. The bromodomain and extra-terminal (BET) proteins are master transcriptional regulators. Despite promising
The base-free van Leusen reaction of cyclic imines on water: Synthesis of N-fused imidazo 6,11-dihydro β-carboline derivatives
Satyam, Killari,Murugesh,Suresh, Surisetti
, p. 5234 - 5238 (2019/06/07)
Construction of imidazoles has been demonstrated on water under base-free conditions. The reaction of dihydro β-carboline imines and p-toluenesulfonylmethyl isocyanides furnished the corresponding substituted N-fused imidazo 6,11-dihydro β-carboline derivatives in very good yields under ambient conditions. The use of deuterium oxide (D2O) as a solvent enabled the incorporation of deuterium isotopes in the imidazole ring.
Shape-selective fluorescent sensing ensemble using a tweezer-type metalloreceptor
Plante, Jeffrey P.,Glass, Timothy E.
, p. 2163 - 2166 (2007/10/03)
A fluorescent sensing ensemble for pyridine-derived compounds is described. The receptor portion of the ensemble is prepared from a bisimidazole pyridine which coordinates copper to form a well-defined cavity. Small heteroaromatic guests such as adenine b
An efficient method for the synthesis of substituted TosMIC precursors
Sisko, Joseph,Mellinger, Mark,Sheldrake, Peter W.,Baine, Neil H.
, p. 8113 - 8116 (2007/10/03)
Substituted tosylmethyl isocyanides (TosMICs) are useful reagents for which no general method of preparation is available. We describe here a high-yielding method for the synthesis of substituted tosylmethyl formamides, which are readily converted to the corresponding isocyanides.
