26342-09-6Relevant articles and documents
Synthesis of neuraminidase-resistant sialoside-modified three-way junction DNA and its binding ability to various influenza viruses
Yamabe, Miyuki,Fujita, Akira,Kaihatsu, Kunihiro,Ebara, Yasuhito
, p. 43 - 50 (2019)
Natural sialic acid-modified compounds are capable of targeting influenza virus hemagglutinin (HA). However, these compounds have limited inhibitory effect because natural O-glycoside bond in these compounds are prone to be cleaved by neuraminidase (NA) on the surface of viruses. In this study, we synthesized NA-resistant sialoside that included unnatural S-glycoside bonds and modified this sialoside on a three-way junction (3WJ) DNA to display complementary distribution to its binding sites on a HA trimer. This S-glycoside-containing sialoside-modified 3WJ DNA showed certain NA resistance and maintained high binding affinity. Importantly, our observations showed that substituting natural O-glycoside with unnatural S-glycoside did not affect the binding affinity of the sialoside-modified 3WJ DNA for viruses. Thus, this study is an important step forward in the development of NA-resistant sialoside derivatives for more effective detection and inhibition of infection by a broad spectrum of viruses.
Pyrrolo pyrrole diketone (DPP) quaternary ammonium salt compound and its preparation and use
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, (2017/07/08)
The invention provides diketopyrrolopyrrole (DPP) quaternary ammonium salt compounds, which are disclosed as the structural formula in the specification, wherein N-R2 is disclosed in the specification, and R1 is Cl, Br, F, I, CF3, CN, tBu, CH3, H, 2,6-F2,
Potential antiradiation agents. I. Primary aminoalkanethiosulfuric acids.
Klayman,Grenan,Jacobus
, p. 510 - 512 (2007/10/05)
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