26342-09-6Relevant academic research and scientific papers
Synthesis of neuraminidase-resistant sialoside-modified three-way junction DNA and its binding ability to various influenza viruses
Yamabe, Miyuki,Fujita, Akira,Kaihatsu, Kunihiro,Ebara, Yasuhito
, p. 43 - 50 (2019)
Natural sialic acid-modified compounds are capable of targeting influenza virus hemagglutinin (HA). However, these compounds have limited inhibitory effect because natural O-glycoside bond in these compounds are prone to be cleaved by neuraminidase (NA) on the surface of viruses. In this study, we synthesized NA-resistant sialoside that included unnatural S-glycoside bonds and modified this sialoside on a three-way junction (3WJ) DNA to display complementary distribution to its binding sites on a HA trimer. This S-glycoside-containing sialoside-modified 3WJ DNA showed certain NA resistance and maintained high binding affinity. Importantly, our observations showed that substituting natural O-glycoside with unnatural S-glycoside did not affect the binding affinity of the sialoside-modified 3WJ DNA for viruses. Thus, this study is an important step forward in the development of NA-resistant sialoside derivatives for more effective detection and inhibition of infection by a broad spectrum of viruses.
Azobenzene side chain polymerizable monomer based on modified cis-5-norbornene-2,3-dicarboxylic anhydride and applications thereof
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Paragraph 0011; 0043-0044, (2020/02/10)
The invention discloses an azobenzene side chain polymerizable monomer based on modified cis-5-norbornene-2,3-dicarboxylic anhydride and applications thereof, wherein a polymerizable monomer is obtained by grafting synthesized azobenzene to norbornene anhydride, polyhydroxy azobenzene as a side chain is linked to the main chain of the norbornene anhydride, and the storage and the release of polymer energy are achieved through intermolecular hydrogen bonding force and cis-trans isomerization of azobenzene. According to the invention, the target polymer is obtained through ring-opening metathesis polymerization; and compared with the common azobenzene molecules, the obtained azobenzene side chain-containing polymer material of the invention has advantages of substantially improved energy density, substantially improved half-life period and good plasticity, so that the new method is provided for solar energy utilization, and the application range of azobenzene polymers is widened.
Pyrrolo pyrrole diketone (DPP) quaternary ammonium salt compound and its preparation and use
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, (2017/07/08)
The invention provides diketopyrrolopyrrole (DPP) quaternary ammonium salt compounds, which are disclosed as the structural formula in the specification, wherein N-R2 is disclosed in the specification, and R1 is Cl, Br, F, I, CF3, CN, tBu, CH3, H, 2,6-F2,
Amination of ω-Functionalized Aliphatic Primary Alcohols by a Biocatalytic Oxidation-Transamination Cascade
Pickl, Mathias,Fuchs, Michael,Glueck, Silvia M.,Faber, Kurt
, p. 3121 - 3124 (2015/10/19)
Amination of non-activated aliphatic fatty alcohols to the corresponding primary amines was achieved through a five-enzyme cascade reaction by coupling a long-chain alcohol oxidase from Aspergillus fumigatus (LCAO-Af) with a ω-transaminase from Chromobacterium violaceum (ω-TA-Cv). The alcohol was oxidized at the expense of molecular oxygen to yield the corresponding aldehyde, which was subsequently aminated by the PLP-dependent ω-TA to yield the final primary amine product. The overall cascade was optimized with respect to pH, O2 pressure, substrate concentration, decomposition of H2O2 (derived from alcohol oxidation), NADH regeneration, and biocatalyst ratio. The substrate scope of this concept was investigated under optimized conditions by using terminally functionalized C4-C11 fatty primary alcohols bearing halogen, alkyne, amino, hydroxy, thiol, and nitrile groups.
