263559-19-9

Basic information

• Product Name: C₂₃H₄₂O₃Si₂
• CAS NO: 263559-19-9
• Molecular Weight: 422.756
• Mol File: 263559-19-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₃H₄₂O₃Si₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₃H₄₂O₃Si₂(263559-19-9)
• EPA Substance Registry System: C₂₃H₄₂O₃Si₂(263559-19-9)

Safety Data

• Hazardous Substances Data: 263559-19-9(Hazardous Substances Data)

Upstream product

• 17071-29-3 ethyl 3-oxo-5-phenylpentanoate 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 153744-07-1 (R)-3-hydroxy-5-phenylvaleric acid 

Downstream Products

• 263559-17-7 (3'R,3S,4S)-1,4-di(4-methoxyphenyl)-3-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-phenylpropyl]azetidin-2-one 
• 263559-23-5 Imidazole-1-carbothioic acid O-{(R)-1-[(2S,3S)-1,2-bis-(4-methoxy-phenyl)-4-oxo-azetidin-3-yl]-3-phenyl-propyl} ester 
• 263559-11-1 (3'R,3S,4S)-1,4-di(4-methoxyphenyl)-3-[(1-hydroxy-3-phenyl)propyl]azetidin-2-one 
• 263559-16-6 (3R)-S-2-pyridylthio 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-phenylvalerate 
• 148260-92-8 SCH 48461 
• 263559-20-2 3-(tert-butyl-dimethyl-silanyloxy)-5-phenyl-pentanoic acid 

Relevant articles and documents

Stereoselective synthesis of 2-azetidinones as cholesterol-absorption inhibitors

The synthesis of two 2-azetidinones possessing powerful cholesterol- absorption inhibition properties has been accomplished by a short and highly stereoselective reaction sequence. The key step is the condensation of the titanium enolate of the easily prepared 2-pyridylthioester (R)-11 with imine 6 which affords the desired β-lactam intermediate in the correct relative and absolute configuration. Conversion to the pharmacologically active compounds is readily accomplished by simple functional group manipulation. (C) 2000 Elsevier Science Ltd.