263559-17-7Relevant articles and documents
Stereoselective synthesis of 2-azetidinones as cholesterol-absorption inhibitors
Annunziata, Rita,Benaglia, Maurizio,Cinquini, Mauro,Cozzi, Franco
, p. 4841 - 4849 (2007/10/03)
The synthesis of two 2-azetidinones possessing powerful cholesterol- absorption inhibition properties has been accomplished by a short and highly stereoselective reaction sequence. The key step is the condensation of the titanium enolate of the easily prepared 2-pyridylthioester (R)-11 with imine 6 which affords the desired β-lactam intermediate in the correct relative and absolute configuration. Conversion to the pharmacologically active compounds is readily accomplished by simple functional group manipulation. (C) 2000 Elsevier Science Ltd.