263769-20-6

Basic information

• Product Name: ethyl (S)-3-benzyloxy-2,2-dimethylbutanoate
• Synonyms: ethyl (S)-3-benzyloxy-2,2-dimethylbutanoate
• CAS NO: 263769-20-6
• Molecular Weight: 250.338
• Mol File: 263769-20-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl (S)-3-benzyloxy-2,2-dimethylbutanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl (S)-3-benzyloxy-2,2-dimethylbutanoate(263769-20-6)
• EPA Substance Registry System: ethyl (S)-3-benzyloxy-2,2-dimethylbutanoate(263769-20-6)

Safety Data

• Hazardous Substances Data: 263769-20-6(Hazardous Substances Data)

Upstream product

• 597-04-6 ethyl 2,2-dimethyl-3-oxobutanoate 
• 79634-82-5 ethyl (S)-2,2-dimethyl-3-hydroxybutanoate 
• 100-39-0 benzyl bromide 

Downstream Products

• 263769-21-7 (4S)-4-benzyloxy-3,3-dimethyl-2-pentanol 

Relevant articles and documents

Asymmetric hydrosilylation of ketones using trans-chelating chiral peralkylbisphosphine ligands bearing primary alkyl substituents on phosphorus atoms

Asymmetric hydrosilylation of simple ketones with diphenylsilane proceeded at -40 °C in the presence of a rhodium complex (0.001 - 0.01 molar amount) coordinated with a trans-chelating chiral bisphosphine ligand bearing linear alkyl substituents on the phosphorus atoms, (R,R)-(S,S)-Et-, Pr-, or BuTRAP, giving the corresponding optically active (S)- secondary alcohols with up to 97% ee. The asymmetric hydrosilylation using TRAP ligands with bulkier P-substituents resulted in much lower enantioselectivities. The EtTRAP-rhodium catalyst was also effective for asymmetric hydrosilylation of keto esters with a coordination site for a rhodium atom (up to 98% ee). Optically active symmetrical diols were obtained with up to 99% ee from the corresponding diketones via the asymmetric reduction using 2.5 molar amounts of diphenylsilane.