2639-34-1Relevant academic research and scientific papers
Access to 2-(het)aryl and 2-styryl benzoxazoles via palladium-catalyzed aminocarbonylation of aryl and vinyl bromides
Neumann, Karoline T.,Lindhardt, Anders T.,Bang-Andersen, Benny,Skrydstrup, Troels
supporting information, p. 2094 - 2097 (2015/05/13)
A sequential one-pot procedure for the synthesis of either 2-(hetero)aryl or 2-styryl benzoxazoles is reported, starting from aryl and vinyl bromides, respectively, involving an initial aminocarbonylation with 2-aminophenols as nucleophiles followed by an acid mediated ring closure to generate the heterocycle. The methodology displays a broad substrate scope in moderate to excellent yields and can be exploited for 13C-isotope labeling. Finally, this carbonylative protocol was applied to the synthesis of a potential Alzheimer's plaque binder and a selective PPAR antagonist including site-specific labeling with 13C-carbon monoxide.
2-STYRYLBENZOXAZOLE DERIVATIVES
Arient, Josef
, p. 3160 - 3165 (2007/10/02)
A series of 35 derivatives of 2-styrylbenzoxazole I-XXXV with methyl, chloro, hydroxy, methoxy, dimethylamino, nitro, cyano and methoxycarbonyl substituents have been prepared by reaction of substituted 2-acetamidophenol with respective benzaldehyde derivatives.
