26410-96-8Relevant articles and documents
Synthesis and relaxometric characterization of a MRI Gd-based probe responsive to glutamic acid decarboxylase enzymatic activity
Napolitano, Roberta,Pariani, Giorgio,Fedeli, Franco,Baranyai, Zsolt,Aswendt, Markus,Aime, Silvio,Gianolio, Eliana
, p. 2466 - 2477 (2013/05/08)
Novel contrast agent based systems, which selectively visualize specific cells, e.g., neurons in the brain, would be of substantial importance for the fast developing field of molecular magnetic resonance imaging (MRI). We report here the synthesis and in vitro validation of a Gd(III)-based contrast agent designed to act as an MRI responsive probe for imaging the activity of the enzyme glutamic acid decarboxylase (GAD) present in neurons. Upon the action of the enzyme, the Gd(III) complex increases its hydration sphere and takes on a residual positive charge that promotes its binding to endogenous macromolecules. Both effects contribute in a synergic way to generate a marked relaxation enhancement, which directly reports enzyme activity and will allow activity detection of GAD positive cells in vitro and in vivo selectively.
Inhibitors of histone deacetylase
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, (2008/06/13)
The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.
Incorporation of aspartate and malate into the pyridine ring of nicotine.
Jackanicz,Byerrum
, p. 1296 - 1299 (2007/10/04)
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