63675-87-6

Upstream product

• 1163701-10-7 (5-methoxy-2-((4-methoxyphenyl)ethynyl)phenyl)(methyl)-sulfane 
• 7163-50-0 (4-methylphenyl)(oxo)acetic acid 
• 7099-91-4 p-methoxybenzoylformic acid 
• 133430-99-6 4-(tert-butyldimethylsilyloxy)iodobenzene 
• 540-38-5 p-Iodophenol 
• 4897-68-1 2-iodo-4-methoxybromobenzene 
• 766-85-8 3-methoxy-1-iodobenzene 
• 5720-07-0 4-methoxyphenylboronic acid 
• 82102-37-2 9-methyl-9H-fluorene-9-carbonyl chloride 
• 264142-55-4 3-iodo-6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene 
• 100-07-2 4-methoxy-benzoyl chloride 
• 63675-74-1 2-(4'-methoxyphenyl)-6-methoxybenzothiophene 

Downstream Products

• 63676-19-7 [6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophen-3-yl](4-hydroxyphenyl)methanone 

Relevant academic research and scientific papers

Method for synthesizing D-Diphenyl formyl-tartaric acid and co-producing methyl benzoate

The invention provides a method for synthesizing D-dibenzoyl tartaric acid and co-producing methyl benzoate. The method comprises the following steps that S1 an organic solvent, D-tartaric acid and lewis acid are added into a reaction bottle, stirred and heated, benzoyl chloride is added dropwise, heat preservation is conducted for 30-90 minutes, a product is cooled to be at 0-5 DEG C, suction filtration is conducted, and a filter cake A and filtrate A are obtained; S2 methyl alcohol is added into the filter cake A and stirred for 30 minutes, suction filtration is conducted, and a filter cakeB and filtrate B are obtained; S3 the filter cake B is added into pure water, heating and back flowing are conducted for 1.5-2.5 hours, a product is cooled to be at 25-30 DEG C, suction filtration isconducted, the filter cake is dried, and D-dibenzoyl tartaric acid is obtained; and S4 an esterification reaction catalyst is added into the filtrate B, back flowing is conducted, alkali is added to adjust the pH value, atmospheric distillation is conducted, water is added to wash the product, vacuum rectification is conducted, and the methyl benzoate is obtained. The method has the advantages that the technology is simple, the operation is convenient, the condition is moderate, the product chromaticity is good, the method is environmentally friendly, the cost is low, the product yield is high, and the product purity is high.

A pizotifen derivative and its preparation method (by machine translation)

The invention discloses a pizotifen derivatives, its molecular formula is The preparation of the pizotifen derivatives raw materials used is simple, its reaction condition is easy to reach, and has a higher yield, in the reaction process also will not produce harmful substances, is a raw material and the reaction conditions are simple pizotifen derivatives. (by machine translation)

Direct synthesis of 3-acylbenzothiophenes: Via the radical cyclization of 2-alkynylthioanisoles with α-oxocarboxylic acids

A radical cascade cyclization of 2-alkynylthioanisoles with α-oxocarboxylic acids with AgNO3 has been described. This reaction provides a novel route to directly access 3-acylbenzothiophenes from simple chemical feedstocks. In particular, the utility of the approach was demonstrated by its application to the synthesis of a polymerization inhibitor and a raloxifene precursor.

Sulfoxide compound and method of producing benzothiophene derivatives using the same

A sulfoxide compound and method of producing benzothiophene derivatives using the same are provided. The sulfoxide compound is represented by formula (I), wherein R1 and R2 are individually and independently benzoyl group; alkyl, acyl or silyl group of C1-C6 straight chain or branched chain; or alkenyl group of C3-C6 straight chain or branched chain; and X is halogen atom. The sulfoxide compound reacts with alkynyl compound, and then the synthesis efficiency of benzothiophene derivatives can be effectively increased.

An air-tolerant approach to the carbonylative suzuki-miyaura coupling: Applications in isotope labeling

Carbonylative Suzuki-Miyaura coupling conditions have been developed that proceed without the exclusion of oxygen and in the presence of nondegassed and nondried solvents. By adapting the method to a two-chamber setup, the direct handling of carbon monoxide, produced from stable CO precursors, is avoided. The protocol afforded the desired benzophenones with excellent functional group tolerance and in good yields. Substituting the CO precursor, in the CO-producing chamber, with its carbon-13 labeled version generated the corresponding carbon-13 labeled benzophenones. Finally, the developed system was applied in the synthesis and isotope labeling of two pharmaceuticals, nordazepam and Tricor.

Benzothiophenes and related compounds as estrogen agonists

The invention is a compound of Formula (I): wherein R is —OH, R1is —OH, R2is —H, n is 2 or 3 and X is sulfur, or a pharmaceutically acceptable salt of a compound having Formula (1), or a pharmaceutical composition comprising a compou

Description anti-mitotic agents which inhibit tubulin polymerization

Methoxy and ethoxy substituted 3-aroyl-2-arylbenzo[b]thiophenes and benzo[b]thiophene analogues are described for use in inhibiting tubulin polymerization. The compounds' use for treating tumor cells is also described. Additional aspects described here are certain diaryl ether benzo[b]thiophene derivatives. Also described are particular analogs derived from dihydronaphthalene which have proven particularly effective. Certain new benzofuran analogs are described, as well as certain sulfur oxide benzo[b]thiophene analogs. Important compounds described herein include the first nitrogen-containing derivatives of combretastatin. These include nitro, amino and azide combrdtastatin derivatives.

Regioselective alkylation process for preparing substituted benzo[b]thiophenes

The present invention provides processes for the regioselective alkylation of benzothiophenes.

Benzothiophene compounds, compositions, and methods

The invention provides benzothiophene compounds, formulations, and methods of inhibiting bone loss or bone resorption, particularly osteoporosis, cardiovascular-related pathological conditions, including hyperlipidemia.

Anti-mitotic agents which inhibit tubulin polymerization

Methoxy and ethoxy substituted 3-aroyl-2-arylbenzo?b!thiophenes and benzo?b!thiophene analogues are described for use in inhibiting tubulin polymerization. The compounds' use for treating tumor cells is also described.