264206-85-1Relevant articles and documents
Discovery of substituted maleimides as liver X receptor agonists and determination of a ligand-bound crystal structure
Jaye, Michael C.,Krawiec, John A.,Campobasso, Nino,Smallwood, Angela,Qiu, Chunyan,Lu, Quinn,Kerrigan, John J.,De Los Frailes Alvaro, Maite,Laffitte, Bryan,Liu, Wu-Schyong,Marino Jr., Joseph P.,Meyer, Craig R.,Nichols, Jason A.,Parks, Derek J.,Perez, Paloma,Sarov-Blat, Lea,Seepersaud, Sheila D.,Steplewski, Klaudia M.,Thompson, Scott K.,Wang, Ping,Watson, Mike A.,Webb, Christine L.,Haigh, David,Caravella, Justin A.,Macphee, Colin H.,Willson, Timothy M.,Collins, Jon L.
, p. 5419 - 5422 (2007/10/03)
Substituted 3-(phenylamino)-1H-pyrrole-2,5-diones were identified from a high throughput screen as inducers of human ATP binding cassette transporter A1 expression. Mechanism of action studies led to the identification of GSK3987 (4) as an LXR ligand. 4 r
Novel method and compounds
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Page/Page column 24, (2010/02/05)
A method for the treatment of conditions associated with a need for inhibition of GSK-3, such as diabetes, dementias such as Alzheimer's disease and manic depression which method comprises the administration of a pharmaceutically effective, non-toxic amou
