26421-44-3

Basic information

• Product Name: 2,5-DIMETHYL-THIOPHENE-3-CARBALDEHYDE
• Synonyms: TIMTEC-BB SBB009464;2,5-DIMETHYL-3-FORMYLTHIOPHENE;2,5-DIMETHYL-THIOPHENE-3-CARBALDEHYDE;2,5-DIMETHYLTHIOPHENE-3-CARBOXALDEHYDE;AKOS B018517;ART-CHEM-BB B018517;2,5-Dimethylthiophene-3-carboxaldehyde 97%
• CAS NO: 26421-44-3
• Molecular Formula: C₇H₈OS
• Molecular Weight: 140.2
• Product Categories: Aldehydes;Thiophenes & Benzothiophenes;Thiophenes & Benzothiophenes
• Mol File: 26421-44-3.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 218 °C at 760 mmHg
• Flash Point: 86 °C
• Appearance: /
• Density: 1.138 g/cm³
• Vapor Pressure: 0.129mmHg at 25°C
• Refractive Index: 1.581
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 2,5-DIMETHYL-THIOPHENE-3-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-DIMETHYL-THIOPHENE-3-CARBALDEHYDE(26421-44-3)
• EPA Substance Registry System: 2,5-DIMETHYL-THIOPHENE-3-CARBALDEHYDE(26421-44-3)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 26421-44-3(Hazardous Substances Data)

Usage

General Description

2,5-DIMETHYL-THIOPHENE-3-CARBALDEHYDE is a chemical compound with the molecular formula C9H10OS. It is a derivative of thiophene, a five-membered aromatic ring containing four carbon atoms and one sulfur atom. The compound has two methyl groups attached to the 2 and 5 positions of the thiophene ring, and a formyl group attached to the 3 position. It is commonly used as a building block in the synthesis of various organic compounds, particularly in the pharmaceutical and agrochemical industries. 2,5-DIMETHYL-THIOPHENE-3-CARBALDEHYDE has a wide range of applications including as a flavoring agent, fragrance, and as an intermediate in the production of various chemicals.

InChI:InChI=1/C7H8OS/c1-5-3-7(4-8)6(2)9-5/h3-4H,1-2H3

Upstream product

• 638-02-8 2,5-DIMETHYLTHIOPHENE 
• 4885-02-3 Dichloromethyl methyl ether 
• 31819-37-1 3-bromo-2,5-dimethylthiophene 
• 68-12-2 N,N-dimethyl-formamide 
• 29421-92-9 4-bromo-2-methylthiophene 
• 13679-70-4 5-methylthiophene-2-carboxaldehyde 
• 498-62-4 3-thiophene carboxaldehyde 
• 25891-31-0 triformylamine 
• 84815-20-3 2-methyl-3-thiophenecarboxaldehyde 
• 74-88-4 methyl iodide 
• 5312-73-2 dichloromethyl n-butyl ether 
• 57248-13-2 2,5-dimethylthiophene-3-carbonyl chloride 
• 93-61-8 N-methyl-N-phenylformamide 

Downstream Products

• 14503-51-6 tetramethylthiophene 
• 63826-44-8 2,4,5-trimethyl-thiophene-3-carbaldehyde 
• 26421-32-9 2,5‐dimethylthiophene‐3‐carboxylic acid 
• 57248-13-2 2,5-dimethylthiophene-3-carbonyl chloride 
• 470704-56-4 3-amino-3-(2,5-dimethylthien-3-yl)propanoic acid 
• 1795-05-7 2,4,5-trimethylthiophene 

Relevant articles and documents

Synthesis and biological evaluation of cyclopenta[c]thiophene related compounds as new antitumor agents

A series of 22 cyclopenta[c]thiophene related compounds was obtained by the pharmacomodulation of 6-amino-5,6-dihydro-4H-cyclopenta[c]thiophen-4-ones 1a-g. All compounds were evaluated for potential anticancer activity in the NCI's in vitro human disease-oriented tumor cell line screening panel that consisted of 60 human tumor cell lines arranged in nine subpanels, representing diverse histologies. Among these tested compounds, seven were found to be cytotoxic, especially against leukemia cell lines, allowing us to point out some structure-activity relationships. These derivatives were further evaluated for potential in vivo anticancer activity in the hollow fiber assay developed at the NCI, which selected two compounds, 1f and 3a for standard xenograft testing.

POLYCYCLIC AMINES AS OPIOID RECEPTOR MODULATORS

The present invention provides a genus of polycyclic amines that are useful as opioid receptor modulators. The compounds of the invention are useful in both therapeutic and diagnostic methods, including for treating pain, neurological disorders, cardiac disorders, bowel disorders, drug and alcohol addiction, drug overdose, urinary disorders, respiratory disorders, sexual dysfunction, psoriasis, graft rejection or cancer.

SUBSTITUTED AMINOTHIAZOLE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE

Substituted aminothiazole derivatives, methods of their preparation, pharmaceutical compositions comprising a substituted aminothiazole, and methods of use in treating human or animal disorders. The compounds may be useful as inhibitors of action of AgRP on a melanocortin receptor and thus may be useful for the management, treatment, control, or the adjunct treatment of diseases which may be responsive to the modulation of melanocortin receptors including obesity-related disorders.