84815-20-3

Usage

Uses

Used in Fragrance and Flavor Industry:
2-Methylthiophene-3-carboxaldehyde is utilized as a component in the fragrance and flavor industry for its ability to contribute to the creation of a variety of aromatic compounds. Its unique properties allow it to enhance the sensory experience of products in this sector.
Used in Pharmaceutical Synthesis:
In the pharmaceutical industry, 2-Methylthiophene-3-carboxaldehyde serves as a key intermediate in the synthesis of various drugs. Its chemical structure makes it a valuable asset in the development of new medicinal compounds.
Used in Agrochemical Synthesis:
Similarly, in the agrochemical sector, 2-Methylthiophene-3-carboxaldehyde is employed in the synthesis of different agrochemicals, contributing to the development of products that aid in crop protection and enhancement of agricultural yields.
Used in Organic Chemistry as a Building Block:
2-Methylthiophene-3-carboxaldehyde is recognized for its potential as a building block in organic chemistry. Its structural features make it a promising candidate for the construction of complex organic molecules.
Used as a Precursor for New Chemical Compounds:
2-Methylthiophene-3-carboxaldehyde is also used as a precursor to create new chemical entities, expanding the scope of chemical research and innovation.
Used for Antimicrobial Properties:
2-Methylthiophene-3-carboxaldehyde has been found to exhibit antimicrobial properties, which makes it potentially useful in applications where control of microbial growth is necessary, such as in certain medical or industrial processes.
Used for Antioxidant Properties:
Its antioxidant properties suggest that 2-Methylthiophene-3-carboxaldehyde could be employed in applications requiring protection against oxidative damage, further broadening its range of uses across various industries.

InChI:InChI=1/C6H6OS/c1-5-6(4-7)2-3-8-5/h2-4H,1H3

Upstream product

• 498-62-4 3-thiophene carboxaldehyde 
• 74-88-4 methyl iodide 
• 30319-05-2 3-bromo-2-methylthiophene 
• 15226-74-1 dicobalt octacarbonyl 
• 857979-28-3 (2-methyl-3-thienyl)methanol 
• 1918-78-1 2-methylthiophene-3-carboxylic acid 
• 13250-82-3 2-(thiophen-3-yl)-1,3-dioxolane 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 26421-44-3 2,5-dimethyl-thiophene-3-carbaldehyde 
• 197723-93-6 (2-methylthien-3-yl)-1-trityl-imidazol-4-yl-methanol 
• 98316-34-8 2-methyl-3-(2-nitrovinyl)thiophene 
• 334918-26-2 (2-methyl-thiophen-3-yl)-(1-trityl-1H-imidazol-4-yl)-methanone 

Relevant academic research and scientific papers

Palladium-Catalyzed Reductive Carbonylation of (Hetero) Aryl Halides and Triflates Using Cobalt Carbonyl as CO Source

An efficient protocol for the reductive carbonylation of (hetero) aryl halides and triflates under CO gas-free conditions using Pd/Co2(CO)8 and triethylsilane has been developed. The mild reaction conditions, enhanced chemoselectivity and, easy access to heterocyclic and vinyl carboxaldehydes highlights its importance in organic synthesis.

Convenient method for the preparation of the 2-methyl thiophen-3-yl magnesium bromide lithium chloride complex and its application to the synthesis of 3-substituted 2-methylthiophenes

Lithium chloride was found to accelerate formation of the Grignard reagent from inactive 3-bromo-2-methylthiophene (1) and commercial magnesium metal. Based on this finding, a convenient and potentially scalable preparation of ethyl 2-methylthiophene-3-ca

NOVEL INDOLE AND PYRROLOPYRIDINE AMIDES

The present invention relates to indole and pyrrolopyridine amide derivatives of formula (I) wherein R1, R 2, R 3, U, V, W, X, Y, Z and ring A are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as orexin receptor antagonists.

Antiinflammation agents

Compounds, compositions and methods that are useful in the treatment of inflammatory, immunoregulatory, metabolic, infectious and cell proliferative diseases or conditions are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, metabolism, infection and cell proliferation. The subject compounds contain a fused heterobicyclic ring.

Fused pyridine derivatives

The present provides a condensed pyridine compound (I) represented by the following formula: (wherein, R2represents ring A represents benzene ring, pyridine ring, thiophene ring or furan ring; and B represents its pharmaceutically acceptable salt or hydrates thereof, which is a clinically useful medicament having a serotonin antagonism, in particular, that for treating, ameliorating or preventing spastic paralysis or central muscle relaxants for ameliorating myotonia.

α2 adrenoceptor agonists as potential analgesic agents. 3. Imidazolylmethylthiophenes

A series of imidazolylmethylthiophenes has been prepared and evaluated as ligands for the α2 adrenoceptor. These compounds were tested in two animal models that are predictive of analgesic activity in humans. The 3-thienyl compounds were generally the most potent, particularly those with substitution in the 4-position. A subset of the most active compounds was further evaluated for adverse cardiovascular effects in the anesthetized rat model. In addition to excellent binding at the α2D adrenoceptor, the 4-bromo analogues 20e and 21e were very active in the rat abdominal irritant test (RAIT) with ED50 doses of 0.38 and 0.31 mg/kg, respectively. We constructed a pharmacophore model based on the biological activity of the present series, dexmedetomidine (1), and conformationally restrained analogues 3 and 4.

4-?(thien-3-yl)methyl!-imidazole analgesics

Described herein are 4-?(thien-3-yl)methyl!-imidazoles of the formula: STR1 wherein R is hydrogen or methyl, and X is C1-4 alkyl, bromine or chlorine; or STR2 wherein Y is hydrogen, C1-4 alkyl, bromine or chlorine, and Z is C1-4

Lithiation of Heterocycles Directed by α-Amino Alkoxides

The addition of heterocyclic aromatic aldehydes to certain lithium dialkylamides gave α-amino alkoxides that were ring-lithiated with butyllithium.Alkylation and hydrolysis provided ring-substituted heterocyclic aromatic aldehydes via a one-pot reaction.The metalation of α-amino alkoxides derived from thiophenecarboxaldehydes, furaldehydes, N-methylpyrrolecarboxaldehydes, and indolecarboxaldehydes was examined.The regioselectivity of the lithiation, was dependent on the heterocycle, the amine component of the α-amino alkoxide, and the metalation conditions.A novel N-methyl metalation of α-amino alkoxides derived from N-methylpyrrole-2-carboxaldehyde and N-methylindole-2-carboxaldehyde was achieved when N,N,N'-trimethylethylenediamine was used as the amine component for in situ formation of the α-amino alkoxides.The novel directed N-methyl lithiations are attributed to an intramolecular TMEDA-like assisted metalation.