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26447-74-5

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26447-74-5 Usage

General Description

2-CHLORO-N-(5,6-DIMETHYL-BENZOTHIAZOL-2-YL)-ACETAMIDE is a chemical compound with the molecular formula C11H11ClN2OS. It is a chlorinated acetamide derivative with a benzothiazole ring. 2-CHLORO-N-(5,6-DIMETHYL-BENZOTHIAZOL-2-YL)-ACETAMIDE is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It has also been studied for its potential applications in the treatment of neurological disorders and various other medical conditions. Additionally, it is known to exhibit various biological activities, including antimicrobial and antifungal properties.

Check Digit Verification of cas no

The CAS Registry Mumber 26447-74-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,6,4,4 and 7 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 26447-74:
(7*2)+(6*6)+(5*4)+(4*4)+(3*7)+(2*7)+(1*4)=125
125 % 10 = 5
So 26447-74-5 is a valid CAS Registry Number.

26447-74-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-chloro-N-(5,6-dimethyl-1,3-benzothiazol-2-yl)acetamide

1.2 Other means of identification

Product number -
Other names 2-Chloracetylamino-5,6-dimethylbenzothiazol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:26447-74-5 SDS

26447-74-5Downstream Products

26447-74-5Relevant articles and documents

Mechanistic insights into binding of ligands with thiazolidinedione warhead to human histone deacetylase 4

Basheer, Sidra,J?nsch, Niklas,Müller, Marlene,Meyer-Almes, Franz-Josef,Ramaa, C. S.,Schweipert, Markus,Tilekar, Kalpana,Upadhyay, Neha,Wozny, Ewelina,Wurster, Eva

, (2021/10/26)

Recently, we have reported that non-hydroxamate thiazolidinedione (TZD) analogs are capable of inhibiting human deacetylase 4 (HDAC4). This study aims at the dissection of the molecular determinants and kinetics of the molecular recognition of TZD ligands by HDAC4. For this purpose, a structure activity relationship analysis of 225 analogs was combined with a comprehensive study of the enzyme and binding kinetics of a variety of HDAC4 mutant variants. The experimental data were rationalized by docking to the two major conformations of HDAC4. TZD ligands are competitive inhibitors and bind via a two-step mechanism involving principal molecular recognition and induced fit. The residence time of 24 g is (34 ± 3) min and thus much larger than that of the canonical pan-HDAC inhibitor SAHA ((5 ± 2) min). Importantly, the binding kinetics can be tuned by varying the structure of the CAP group.

SUBSTITUTED HETEROCYCLIC COMPOUNDS

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Page 27, (2008/06/13)

Disclosed are novel heterocyclic derivatives, useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, and myocardial infarction. The compounds are also useful in the treatment of diabetes.

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