26453-01-0

Basic information

• Product Name: 2,3-Dihydro-1H-indene-2-carbonitrile
• Synonyms: 2,3-Dihydro-1H-indene-2-carbonitrile;Indan-2-carbonitrile, 98%
• CAS NO: 26453-01-0
• Molecular Formula: C10H9N
• Molecular Weight: 143.18516
• Mol File: 26453-01-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 290.4±29.0 °C(Predicted)
• Appearance: /
• Density: 1.09±0.1 g/cm3(Predicted)
• CAS DataBase Reference: 2,3-Dihydro-1H-indene-2-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-Dihydro-1H-indene-2-carbonitrile(26453-01-0)
• EPA Substance Registry System: 2,3-Dihydro-1H-indene-2-carbonitrile(26453-01-0)

Safety Data

• Hazardous Substances Data: 26453-01-0(Hazardous Substances Data)

Usage

General Description

2,3-Dihydro-1H-indene-2-carbonitrile is a chemical compound with the molecular formula C11H9N. It is a colorless to pale yellow liquid that is used in organic synthesis as a building block for the production of pharmaceuticals, agrochemicals, and dyes. It is also used as a precursor for the synthesis of other important chemical compounds. 2,3-Dihydro-1H-indene-2-carbonitrile is considered to be potentially hazardous to human health as it is a skin and eye irritant, and may cause respiratory irritation if inhaled. It is important to handle this compound with caution and adhere to proper safety protocols when working with it.

Upstream product

• 777-72-0 methansulfonic acid 2,3-dihydro-1H-inden-2-yl ester 
• 143-33-9 sodium cyanide 
• 557-21-1 zinc(II) cyanide 
• 83094-62-6 2-chloro-2,3-dihydro-1H-indene 
• 612-12-4 o-Xylylene dichloride 
• 105-56-6 ethyl 2-cyanoacetate 
• 557-21-1 dicyanozinc 
• 13435-20-6 tetraethylammoniumcyanide 
• 4254-29-9 indan-2-ol 

Downstream Products

• 146737-65-7 1H-indene-2-methanamine, 2,3-dihydro 
• 175079-50-2 2-Carbamoylindane 
• 209225-01-4 5-nitroindane-2-carboxylic acid 
• 209225-00-3 4-nitro-2,3-dihydro-1H-indene-2-carboxylic acid 
• 391655-29-1 {5-[(6-methyl-4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-indan-2-ylmethyl}-carbamic acid methyl ester 
• 391655-35-9 {5-[(4'-chloro-6-methyl-biphenyl-2-carbonyl)-amino]-indan-2-ylmethyl}-carbamic acid methyl ester 
• 1027408-38-3 6-methyl-4'-trifluoromethyl-biphenyl-2-carboxylic acid (2-aminomethyl-indan-5-yl)-amide 

Relevant articles and documents

Nickel-Catalyzed Cyanation of Unactivated Alkyl Sulfonates with Zn(CN)2

Cyanation of unactivated primary and secondary alkyl mesylates with Zn(CN)2 catalyzed by nickel has been developed. The reaction provides an efficient route for the synthesis of alkyl nitriles with wide substrate scope, good functional group tolerance, and compatibility with heterocyclic compounds. Mechanistic studies indicate that alkyl iodide generated in situ serves as the reactive intermediate and the gradual release of alkyl iodide is crucial for the success of the reaction.

Novel method for synthesizing 2-amine indene

The invention provides a novel method for synthesizing 2-amine indene. The novel method includes carrying out nucleophilic substitution reaction on bisbenzene and ethyl cyanoacetate and carrying out decarboxylation procedures to obtain compounds 15; carrying out hydrolysis to obtain compounds 16; ultimately carrying out Hofmann degradation reaction to obtain the 2-amine indene which is a target product. The bisbenzene is a chemical material and is used as a main raw material for the 2-amine indene. Compared with the prior art, the novel method has the advantages that the novel method is shortin reaction path and suitable for industrial large-scale production, raw materials are low in cost and are easily available, reaction conditions are mild, the productivity can be obviously improved, and the production cycle can be obviously shortened.

AMINOMETHYL SUBSTITUTED BICYCLIC AROMATIC COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF THE DOPAMINE D3 RECEPTOR

The present invention relates to an aminomethyl substituted bicyclic aromatic compound of the formula (I) wherein Ar is a cyclic radical selected from the group consisting of phenyl, a 5- or 6-membered C-bound heteroaromatic radical comprising as ring mem