2,3-Dihydro-1H-indene-2-carbonitrile

Base Information

• Chemical Name: 2,3-Dihydro-1H-indene-2-carbonitrile
• CAS No.: 26453-01-0
• Molecular Formula: C10H9N
• Molecular Weight: 143.18500
• Hs Code.: 2926909090
• Mol file: 26453-01-0.mol

Synonyms:2-Cyanoindan;indane-2-carbonitrile;indan-2-carbonitrile;2,3-dihydro-1H-indene-2-carbonitrile;2-cyanoindane;

Chemical Property of 2,3-Dihydro-1H-indene-2-carbonitrile

Chemical Property:

• Boiling Point: 290.4±29.0 °C(Predicted)
• PSA: 23.79000
• Density: 1.09±0.1 g/cm3(Predicted)
• LogP: 1.92498

Purity/Quality:

97% ^*data from raw suppliers

Indan-2-carbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,3-Dihydro-1H-indene-2-carbonitrile

There total 7 articles about 2,3-Dihydro-1H-indene-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

zinc(II) cyanide (557-21-1) + 2-chloro-2,3-dihydro-1H-indene (83094-62-6) → 1H-indene-2-carbonitrile, 2,3-dihydro- (26453-01-0)

Guidance literature:

With dmap; nickel(II) chloride hexahydrate; tetrabutyl-ammonium chloride; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; zinc; In acetonitrile; at 100 ℃; for 8h; Inert atmosphere; Glovebox;

Reference yield: 81.0%

2-chloro-2,3-dihydro-1H-indene (83094-62-6) + dicyanozinc (557-21-1) → 1H-indene-2-carbonitrile, 2,3-dihydro- (26453-01-0)

Guidance literature:

With dmap; nickel(II) chloride hexahydrate; tetrabutyl-ammonium chloride; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; zinc; In acetonitrile; at 100 ℃; for 8h; Inert atmosphere;

DOI:10.1021/acs.orglett.8b03539

Reference yield: 77.0%

zinc(II) cyanide (557-21-1) + methansulfonic acid 2,3-dihydro-1H-inden-2-yl ester (777-72-0) → 1H-indene-2-carbonitrile, 2,3-dihydro- (26453-01-0)

Guidance literature:

With dmap; nickel(II) chloride hexahydrate; tetra-(n-butyl)ammonium iodide; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; zinc; In acetonitrile; at 100 ℃; for 10h; Inert atmosphere;

DOI:10.1021/acs.orglett.0c02722

upstream raw materials:

methansulfonic acid 2,3-dihydro-1H-inden-2-yl ester

sodium cyanide

indan-2-ol

tetraethylammoniumcyanide

Downstream raw materials:

1H-indene-2-methanamine, 2,3-dihydro

6-methyl-4'-trifluoromethyl-biphenyl-2-carboxylic acid (2-aminomethyl-indan-5-yl)-amide

{5-[(4'-chloro-6-methyl-biphenyl-2-carbonyl)-amino]-indan-2-ylmethyl}-carbamic acid methyl ester

{5-[(6-methyl-4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-indan-2-ylmethyl}-carbamic acid methyl ester