26475-62-7

Usage

Uses

Used in Chemical Reactions:
4-(2-HYDROXYETHYL)THIOMORPHOLINE 1,1-DIOXIDE is used as a reagent for its ability to form hydrogen bonds, facilitating specific chemical reactions that require such interactions.
Used in Industrial Applications:
In various industries, 4-(2-HYDROXYETHYL)THIOMORPHOLINE 1,1-DIOXIDE is used as a component in the production of different products due to its unique structural properties and reactivity.
Used in Pharmaceutical Industry:
4-(2-HYDROXYETHYL)THIOMORPHOLINE 1,1-DIOXIDE is used as an intermediate in the synthesis of pharmaceutical compounds, leveraging its chemical properties to contribute to the development of new drugs.
Used in Material Science:
4-(2-HYDROXYETHYL)THIOMORPHOLINE 1,1-DIOXIDE is used as a modifier or additive in material science to enhance the properties of various materials, such as improving solubility or stability.

InChI:InChI=1/C6H13NO3S/c8-4-1-7-2-5-11(9,10)6-3-7/h8H,1-6H2

Upstream product

• 77-77-0 Divinyl sulfone 
• 141-43-5 ethanolamine 
• 7617-67-6 1-bromo-2-(2-bromoethanesulfonyl)ethane 
• 39093-93-1 thiomorpholine 1,1-dioxide 
• 540-51-2 2-bromoethanol 

Downstream Products

• 205193-71-1 4-(4-chloro-2-fluoroanilino)-7-(2-(1,1-dioxothiomorpholino)ethoxy)-6-methoxyquinazoline 
• 125534-05-6 4-(2-(1,1-dioxothiomorpholin-4-yl)ethoxy)benzaldehyde 
• 1392314-28-1 N,N-bis(2-(1,1-dioxido-4-thiomorpholinyl)ethyl)-2-nitrobenzenesulfonamide 
• 1392314-60-1 methyl 4-((1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-3a-((2-(1,1-dioxido-4-thiomorpholinyl)ethyl)amino)-1-isopropenyl-5a,5b,8,8,11a-pentamethyl-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1H-cyclopenta[a]chrysen-9-yl)benzoate 
• 55160-66-2 4-(2-chloroethyl)thiomorpholine 1,1-dioxide 
• 1392311-72-6 4-((1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-3a-(((2-(1,1-dioxido-4-thiomorpholinyl)ethoxy)carbonyl)amino)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-5a,5b,8,8,11a-pentamethyl-1-(1-methylethenyl)-1H-cyclopenta[a]chrysen-9-yl)benzoic acid 

Relevant academic research and scientific papers

Development of a Safe and High-Throughput Continuous Manufacturing Approach to 4-(2-Hydroxyethyl)thiomorpholine 1,1-Dioxide

Continuous processing enabled the highly energetic double conjugate addition of ethanolamine to divinylsulfone to prepare 2 kg of 4-(2-hydroxyethyl)thiomorpholine 1,1-dioxide, as an intermediate in the synthesis of HIV Maturation Inhibitor BMS-955176. In situ IR was employed to monitor the steady state of the transformation for increased robustness via appearance of the thiomorpholine dioxide moiety and disappearance of the divinylsulfone. Surprisingly, a series of oligomers formed as intermediates, which converted to product with extended aging or heating, consistent with computational predictions. By running this process in flow, the highly exothermic reaction could be safely executed in an equal volume of water as the only solvent, despite an adiabatic temperature rise of 142 °C, leading to a streamlined and efficient process.

C-3 NOVEL TRITERPENE WITH C-17 AMINE DERIVATIVES AS HIV INHIBITORS

The present invention relates to to C-3 novel triterpene with C-17 amine derivatives of formula (I); or pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, prodrugs, compositions or combination thereof, wherein R1, R2, R3, R4, R5 and 'n' are as defined herein. The present invention also relates to pharmaceutical compositions comprising compounds of formula (I) and process for preparing them, and their use for the treatment of viral diseases and particularly HIV mediated diseases.