264882-01-1

Basic information

• Product Name: methyl 3-chlorophenyldiazoacetate
• Synonyms: methyl 3-chlorophenyldiazoacetate
• CAS NO: 264882-01-1
• Molecular Weight: 210.62
• Mol File: 264882-01-1.mol

Chemical Properties

• CAS DataBase Reference: methyl 3-chlorophenyldiazoacetate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3-chlorophenyldiazoacetate(264882-01-1)
• EPA Substance Registry System: methyl 3-chlorophenyldiazoacetate(264882-01-1)

Safety Data

• Hazardous Substances Data: 264882-01-1(Hazardous Substances Data)

Upstream product

• 53088-68-9 methyl 3-chlorophenylacetate 
• 1878-66-6 4-chlorophenylacetic Acid 
• 1878-65-5 3-chlorophenylacetic acid 
• 941-55-9 4-toluenesulfonyl azide 

Downstream Products

• 153294-00-9 (R)-3-chloromandelic acid methyl ester 
• 32222-44-9 (S)-(-)-methyl 2-(3-chlorophenyl)-2-hydroxyacetate 
• 1011458-44-8 ethyl 2-[(p-chloro-o-methoxycarbonylmethyl)phenyl]-2-(phenylthio)acetate 
• 1104927-46-9 methyl 2-(9-anthrylmethoxy)-3-(4-methoxyphenylamino)-3-(4-bromophenyl)-2-(3-chlorophenyl)propanoate 
• 1191034-50-0 methyl (R)-2-(3-chlorophenyl)-2-(cyclohexa-2,5-dien-1-yl)acetate 
• 1186207-72-6 methyl 2-(3-chlorophenyl)-2-(1,2-dihydro-2,3-diphenylisoquinolin-1-yl)-2-hydroxyacetate 

Relevant articles and documents

Blue Light-Emitting Diode-Mediated in Situ Generation of Pyridinium and Isoquinolinium Ylides from Aryl Diazoesters: Their Application in the Synthesis of Diverse Dihydroindolizine

Blue light-emitting diode-mediated environmentally sustainable three component reactions among pyridine/isoquinoline 1/2, aryl diazoesters 3, and acrylic ester/3-alkenyl oxindoles 5/6 provide various dihydroindolizines 7 to 9 in excellent yield. The principle of the strategy is photolytic generation of nitrogen ylides from N-heteroarenes and aryl diazoesters and their subsequent [3 + 2] cycloaddition reaction with dipolarophiles. Detailed mechanistic analysis of the transformation through control experiments establishes this strategy as the foundation for the photolytic multicomponent reaction.

2-azabicyclo [3.2.0] compound as well as synthesis method and application

The invention discloses a 2-azabicyclo [3.2.0] compound as well as a synthesis method and an application. The 2-azabicyclo [3.2.0] compound comprises a compound with a structure as shown in a formula I and pharmaceutically acceptable salts thereof, wherein R is a substituted or unsubstituted benzene ring, a C1-8 aliphatic group or trifluoromethyl, R1 and R2 are respectively a substituted or unsubstituted benzene ring, a hydrogen atom or a C1-8 aliphatic group, R3 is a substituted or unsubstituted benzene ring, a hydrogen atom, a C1-8 aliphatic group or a heterocyclic substituent, R4 is a heterocyclic substituent or a substituted or unsubstituted benzene ring, R5 is a C1-8 fatty group, a benzyl group or -COOR6, and R6 is a C1-4 fatty group or a benzyl group. The invention belongs to the technical field of pharmaceutical chemicals, and after the prepared 2-azabicyclo [3.2.0] compound acts on an animal body, anti-sedation and anti-hypnosis effects can be achieved by adjusting the intracerebral level of histamine.

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A visible-light-promoted O-H insertion reaction between 2-pyridones and α-aryldiazoacetates has been developed. Upon visible light irradiation, the reaction proceeds smoothly under mild and catalyst-free conditions. A wide scope of 2-pyridones and α-aryldiazoacetates are well tolerated, and various O-alkylated 2-pyridones are obtained with perfect selectivity and good functional group tolerance. A photoinduced radical process is probably responsible for the excellent selectivity. This journal is

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Pd-Catalyzed Decarboxylative Olefination: Stereoselective Synthesis of Polysubstituted Butadienes and Macrocyclic P-glycoprotein Inhibitors

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