264885-99-6Relevant articles and documents
Oligomeric building block approach to the synthesis of diastereomerically pure pentathymidine 3′,5′-methanephosphonates
Pyzowski, Jaroslaw,Wozniak, Lucyna A.,Stec, Wojciech J.
, p. 771 - 773 (2000)
formula presented A method for a large-scale synthesis of stereodefined oligo(nucleoside 3′,5′-methanephosphonates) has been developed, based on transient 3′-O protection, which allows for the conversion of the protecting chirally defined methanephosphonanilidate group, located at the 3′ end of a stereoregular oligomer, into diastereomerically pure oligomeric building blocks for stereospecific coupling with the 5′-OH group of another oligonucleotide.