264885-99-6

Upstream product

• 90865-76-2 (S_P)-5'-O-DMT-thymidylyl-(3',5')-3'-O-acetylthymidine 3'-methanephosphonate 
• 129395-81-9 (S)-Methyl-phosphonothioic acid O-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-methyl ester 
• 21090-30-2 3'-O-acetylthymidine 

Relevant academic research and scientific papers

Oligomeric building block approach to the synthesis of diastereomerically pure pentathymidine 3′,5′-methanephosphonates

formula presented A method for a large-scale synthesis of stereodefined oligo(nucleoside 3′,5′-methanephosphonates) has been developed, based on transient 3′-O protection, which allows for the conversion of the protecting chirally defined methanephosphonanilidate group, located at the 3′ end of a stereoregular oligomer, into diastereomerically pure oligomeric building blocks for stereospecific coupling with the 5′-OH group of another oligonucleotide.