26503-90-2Relevant academic research and scientific papers
Rhodium (III) analogues of antitumour-active ruthenium(III) compounds: The crystal structure of [ImH] [trans-RhCl4(Im)2] (Im = imidazole)
Mestroni, Giovanni,Alessio, Enzo,Sessanta O Santi, Andrea,Geremia, Silvano,Bergamo, Alberta,Sava, Gianni,Boccarelli, Angela,Schettino, Angela,Coluccia, Mauro
, p. 62 - 71 (1998)
A series of neutral and anionic Rh(III)-chloride compounds bearing ammonia or imidazole (Im) ligands, and isostructural to Ru(III) complexes endowed with antineopiastic activity, were synthesized and characterized spectroscopically. The X-ray crystal structure of [ImH] [trans-RhCl4(Im)2] was determined. Crystal data: monoclinic, space group C2/c, Z = 4, a = 13.133(3), b = 7.977(1), c = 16.683(4) ?, β = 113.84(2)°. The solution behaviour and some biological parameters of the new rhodium compounds, including cytotoxicity, in vitro interactions with DNA and in vivo antitumour activity against a tumour model, were investigated and compared with those of the corresponding ruthenium analogues.
