Rhodium (III) analogues of antitumour-active ruthenium(III) compounds: The crystal structure of [ImH] [trans-RhCl4(Im)2] (Im = imidazole)

Article abstract of DOI:10.1016/s0020-1693(97)05915-x

A series of neutral and anionic Rh(III)-chloride compounds bearing ammonia or imidazole (Im) ligands, and isostructural to Ru(III) complexes endowed with antineopiastic activity, were synthesized and characterized spectroscopically. The X-ray crystal structure of [ImH] [trans-RhCl₄(Im)₂] was determined. Crystal data: monoclinic, space group C2/c, Z = 4, a = 13.133(3), b = 7.977(1), c = 16.683(4) ?, β = 113.84(2)°. The solution behaviour and some biological parameters of the new rhodium compounds, including cytotoxicity, in vitro interactions with DNA and in vivo antitumour activity against a tumour model, were investigated and compared with those of the corresponding ruthenium analogues.