265119-94-6

Basic information

• Product Name: (2,2-DIMETHYL-2,3-DIHYDRO-BENZOFURAN-7-YLOXY)-ACETIC ACID
• Synonyms: TIMTEC-BB SBB007500;(2,2-DIMETHYL-2,3-DIHYDRO-BENZOFURAN-7-YLOXY)-ACETIC ACID;ASINEX-REAG BAS 13027328;2-[(2,2-dimethyl-3H-1-benzofuran-7-yl)oxy]acetic acid;2-[(2,2-dimethyl-3H-1-benzofuran-7-yl)oxy]ethanoic acid;2-[(2,2-dimethyl-3H-benzofuran-7-yl)oxy]acetic acid;A3272/0139196;AO-080/43342583
• CAS NO: 265119-94-6
• Molecular Formula: C12H14O4
• Molecular Weight: 222.24
• Mol File: 265119-94-6.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2,2-DIMETHYL-2,3-DIHYDRO-BENZOFURAN-7-YLOXY)-ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (2,2-DIMETHYL-2,3-DIHYDRO-BENZOFURAN-7-YLOXY)-ACETIC ACID(265119-94-6)
• EPA Substance Registry System: (2,2-DIMETHYL-2,3-DIHYDRO-BENZOFURAN-7-YLOXY)-ACETIC ACID(265119-94-6)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 265119-94-6(Hazardous Substances Data)

Usage

General Description

(2,2-DIMETHYL-2,3-DIHYDRO-BENZOFURAN-7-YLOXY)-ACETIC ACID is a chemical compound that belongs to the class of acetic acid derivatives. It is characterized by its benzofuran structure, which consists of a benzene ring fused to a furan ring. The presence of a dimethyl group at the 2 and 3 positions and an acetoxy group attached to the benzofuran ring distinguishes this compound. It has potential applications in the pharmaceutical and chemical industries due to its unique structure and possible biological activities. Further research and study are needed to uncover its full range of properties and potential uses.

Upstream product

• 1563-38-8 2,3-dihydro-2,2-dimethylbenzofuran-7-ol 
• 105-36-2 ethyl bromoacetate 
• 79-11-8 chloroacetic acid 

Relevant articles and documents

Highly Potent Host-Specific Small-Molecule Inhibitor of Paramyxovirus and Pneumovirus Replication with High Resistance Barrier

Multiple enveloped RNA viruses of the family Paramyxoviridae and Pneumoviridae, like measles virus (MeV), Nipah virus (NiV), canine distemper virus (CDV), or respiratory syncytial virus (RSV), are of high clinical relevance. Each year a huge number of lives are lost as a result of these viral infections. Worldwide, MeV infection alone is responsible for over a hundred thousand deaths each year despite available vaccine. Therefore, there is an urgent need for treatment options to counteract these viral infections. The development of antiviral drugs in general stands as a huge challenge due to the rapid emergence of viral escape mutants. Here, we disclose the discovery of a small-molecule antiviral, compound 1 (ZHAWOC9045), active against several pneumo-/paramyxoviruses, including MeV, NiV, CDV, RSV, and parainfluenza virus type 5 (PIV-5). A series of mechanistic characterizations revealed that compound 1 targets a host factor which is indispensable for viral genome replication. Drug resistance profiling against a paramyxovirus model (CDV) demonstrated no detectable adaptation despite prolonged time of investigation, thereby mitigating the rapid emergence of escape variants. Furthermore, a thorough structure-activity relationship analysis of compound 1 led to the invention of 100-times-more potent-derivatives, e.g., compound 2 (ZHAWOC21026). Collectively, we present in this study an attractive host-directed pneumoviral/paramyxoviral replication inhibitor with potential therapeutic application.

5-benzofuran-1, 3, 4-thiadiazole-2-substituted amide compound and preparation method and application thereof

The invention provides a 5-benzofuran-1, 3, 4-thiadiazole-2-substituted amide compound and a preparation method and application of the 5-benzofuran-1, 3, 4-thiadiazole-2-substituted amide compound, and the 5-benzofuran-1, 3, 4-thiadiazole-2-substituted amide compound is shown as a formula (I). The preparation method of the compound or the pharmaceutically acceptable salt thereof is simple, the yield is high, the cost is low, and the obtained 5-benzofuran-1, 3, 4-thiadiazole-2-substituted amide compound or the pharmaceutically acceptable salt thereof has relatively high activity on plant pathogenic bacteria such as downy mildew and powdery mildew, has a good prevention and treatment effect, can be used as an alternative drug of a plant bactericide, and has a wide application prospect.